Risk Factors for Diabetes Mellitus in Women with Primary Ovarian Insufficiency

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dc.contributor.authorKulaksızoğlu, Mustafa
dc.contributor.authorİpekçi, Süleyman Hilmi
dc.contributor.authorKebapçılar, Levent
dc.contributor.authorKebapçılar, Ayşe Gül
dc.contributor.authorKorkmaz, Hüseyin
dc.contributor.authorAkyürek, Fikret
dc.contributor.authorBaldane, Süleyman
dc.date.accessioned2020-03-26T18:43:14Z
dc.date.available2020-03-26T18:43:14Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPrimary ovarian insufficiency (POI) is not only a gynecological problem but also has serious effects on women's health such as changes in hormone levels that can trigger fluctuations in blood sugar level and inflammation status. The present study was designed to determine vitamin D, copper, zinc, metabolic parameters [insulin, homeostasis model of assessment-insulin resistance (HOMA-IR)], inflammation parameters such as procalcitonin and high sensitivity C reactive protein (hs-CRP), and lipid profile in POI patients and control subjects with normal menstrual cycles. A total of 43 patients with nondiabetic POI were studied in order to evaluate and compare the findings with those of the control group, which comprised 33 women with normal menstrual cycles. The women with POI had higher levels of serum copper, serum insulin, glucose, LDL-cholesterol, total cholesterol, HOMA-IR, hs-CRP, and procalcitonin, whereas serum vitamin D and zinc levels were lower compared with the healthy control group. Follicle-stimulating hormone (FSH) levels were positively correlated with insulin, glucose, HOMA-IR, hs-CRP, procalcitonin, and copper and negatively correlated with vitamin D and zinc levels. In multivariate statistic analyses with body mass index and FSH as dependent variables, FSH was positively associated with copper and HOMA-IR negatively with vitamin D levels. The present study demonstrated that women with POI have traditional risk factors for diabetes mellitus, including lower levels of vitamin D, whereas higher levels of copper and HOMA-IR.en_US
dc.identifier.doi10.1007/s12011-013-9738-0en_US
dc.identifier.endpage320en_US
dc.identifier.issn0163-4984en_US
dc.identifier.issue3en_US
dc.identifier.pmid23812652en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage313en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s12011-013-9738-0
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29793
dc.identifier.volume154en_US
dc.identifier.wosWOS:000323276100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHUMANA PRESS INCen_US
dc.relation.ispartofBIOLOGICAL TRACE ELEMENT RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPOIen_US
dc.subjectCopperen_US
dc.subjectZincen_US
dc.subjectInsulinen_US
dc.subjectHOMA-IRen_US
dc.subjectProcalcitoninen_US
dc.subjecths-CRPen_US
dc.titleRisk Factors for Diabetes Mellitus in Women with Primary Ovarian Insufficiencyen_US
dc.typeArticleen_US

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