The Effect of Natrium Hyaluronate Applied Locally for Pelviureteral Anastomoses

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dc.contributor.authorYurtcu, Muslim
dc.contributor.authorBaba, Zeliha Fusun
dc.date.accessioned2020-03-26T18:43:55Z
dc.date.available2020-03-26T18:43:55Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.descriptionMeeting of the Turkish-Association-of-Pediatric-Surgeons -- 40680 -- Istanbul, TURKEYen_US
dc.description.abstractObjectives: This study aimed to investigate the effect of natrium hyaluronate (NH) on fibrous tissue formation and wound healing in experimental pelviureteral anastomosis (PUA). Materials and methods: Eighteen rabbits were divided equally into three groups: surgical (S), sham (Sh), and NH. A 1-cm length of the ureteropelvic segment was resected through a laparotomy incision and then anastomosis was performed. The rabbits were injected with saline (Sh group) and NH (NH group) into anastomoses lines after the surgical procedure. The S group did not receive any medication during their procedure. Intravenous pyelography was carried out on postoperative day 21. The rabbits were sacrificed and dissected under a dissecting microscope and examined for acute inflammation (AI), chronic inflammation (CI), granulation tissue amount (GTA), granulation tissue fibroblast maturation (GTFM), collagen deposition (CD), neovascularization (N), re-epithelialization (R), and peripheral tissue reaction (PTR) in the anastomosis lines 3 weeks later. Main findings: There were no significant differences in the GTFM scores in the S group compared with those in the NH group. In the NH group, N scores were higher than they were in the S group. Re-epithelialization in the NH group was higher than it was in the S group. Principle conclusions: NH did not decrease fibrosis, but increased important parameters in wound healing such as neovascularization and re-epithelialization in an experimental model of PUA in rabbits.en_US
dc.description.sponsorshipTurkish Assoc Pediat Surgen_US
dc.identifier.doi10.3109/0886022X.2012.734938en_US
dc.identifier.endpage142en_US
dc.identifier.issn0886-022Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid23157161en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage138en_US
dc.identifier.urihttps://dx.doi.org/10.3109/0886022X.2012.734938
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29912
dc.identifier.volume35en_US
dc.identifier.wosWOS:000313670000024en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCAREen_US
dc.relation.ispartofRENAL FAILUREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectnatrium hyaluronateen_US
dc.subjectpelviureteral anastomosesen_US
dc.subjectneovascularizationen_US
dc.subjectre-epithelializationen_US
dc.titleThe Effect of Natrium Hyaluronate Applied Locally for Pelviureteral Anastomosesen_US
dc.typeArticleen_US

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