The efficacy of intrathecal administration of a very low dose potirelin after acute spinal cord injury

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dc.contributor.authorCengiz, Sahika Liva
dc.contributor.authorUstun, Mehmet Erkan
dc.contributor.authorTopcu, Cemile
dc.contributor.authorAhmet, A. K.
dc.date.accessioned2020-03-26T17:28:08Z
dc.date.available2020-03-26T17:28:08Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and object: The objective of this study was to determine the effect of a very tow dose protirelin in cerebrospinal fluid (CSF) glucose, magnesium and lactate levels after spinal cord trauma (SCT) in rabbits. We also aimed to evaluate whether this very tow dose might induce analeptic effect. Material and methods: Twenty rabbits were divided equally into two groups: group I (n = 10) was the control group, suffered from SCT but received only saline after SCT. Group II (n = 10) (treatment group), received a very low dose of 0.05 mg/kg thyrotropin releasing hormone (TRH), analogue protirelin intrathecally after SCT. The basal CSF glucose, magnesium and lactate levels were recorded in both groups. CSF lactate, glucose and magnesium contents were recorded at the same time (an hour before and after) SCT Serum thyroid stimulating hormone (TSH), freetriiodothyronine (73) and freethyroxine (FT4) were measured in all rabbits before and after SCT. Results: Before spinal cord trauma, there were not any significant differences in glucose, lactate and magnesium Levels between group I and II whereas, after spinal cord trauma in group 11, the significant suppression in elevation of Lactate and glucose depletion (p < 0.05) were observed white no significant suppression was observed in magnesium level (p > 0.05) as compared with group I (Table 3). In respect of serum TSH levels, there were not any significant differences between two groups before and after SCT. Conclusions: This study showed that intrathecal TRH has no analeptic effect on serum TSH, FT3 and FT4 levels but can attenuate the increase of lactate levels following spinal cord trauma. No significant decrease in magnesium level and also suppression of glucose decline in group II, may be related to the neuroprotective effects of TRH. (C) 2008 Published by Elsevier Ltd.en_US
dc.identifier.doi10.1016/j.injury.2008.05.006en_US
dc.identifier.endpage1407en_US
dc.identifier.issn0020-1383en_US
dc.identifier.issn1879-0267en_US
dc.identifier.issue12en_US
dc.identifier.pmid19036363en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1403en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.injury.2008.05.006
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22720
dc.identifier.volume39en_US
dc.identifier.wosWOS:000262072900012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofINJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJUREDen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGlucoseen_US
dc.subjectLactateen_US
dc.subjectMagnesiumen_US
dc.subjectProtirelinen_US
dc.subjectSpinal cord traumaen_US
dc.subjectThyrotropin releasing hormoneen_US
dc.titleThe efficacy of intrathecal administration of a very low dose potirelin after acute spinal cord injuryen_US
dc.typeArticleen_US

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