The effect of environmental tobacco smoke on the dose requirements of rocuronium in children

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dc.contributor.authorReisli, R
dc.contributor.authorApilliogullari, S
dc.contributor.authorReisli, I
dc.contributor.authorTuncer, S
dc.contributor.authorErol, A
dc.contributor.authorOkesli, S
dc.date.accessioned2020-03-26T16:55:32Z
dc.date.available2020-03-26T16:55:32Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Smoking affects the pharmacodynamic and pharmacokinetic behaviour of several drugs. The aim of this study was to evaluate the effects of environmental tobacco smoke on onset and recovery time after single dose rocuronium in children. Methods: Forty children between 4 and 10 years were enrolled into the study. Children who have no familial smoking history were included in the first group whereas passive smokers included in the second group. Sevoflurane in 50% O-2 and 50% N2O was used for induction of anaesthesia. Evoked adductor pollicis electromyography was used to monitor neuromuscular block. The T-95 and T-25 values were recorded. Results: The T-95 values (+/-SD) for rocuronium were 110.1 +/- 39.3 s and 79.3 +/- 35.6 s for group 1 and group 2, respectively (P < 0.05). The T-25 value of group 2 was 40.1 +/- 10.6 min and compared with group 1 values (30.85 +/- 7.02 min) it was significantly longer (P < 0.01). Conclusion: This study shows that passive smoking children consume less rocuronium than nonsmokers during similar anaesthesia. We think that a history of passive smoking must also be taken into consideration during preoperative evaluation of paediatric patients.en_US
dc.identifier.doi10.1046/j.1460-9592.2003.01186.xen_US
dc.identifier.endpage250en_US
dc.identifier.issn1155-5645en_US
dc.identifier.issue3en_US
dc.identifier.pmid14996264en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage247en_US
dc.identifier.urihttps://dx.doi.org/10.1046/j.1460-9592.2003.01186.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19232
dc.identifier.volume14en_US
dc.identifier.wosWOS:000222055100007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBLACKWELL PUBLISHING LTDen_US
dc.relation.ispartofPEDIATRIC ANESTHESIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectrocuroniumen_US
dc.subjectpassive smokingen_US
dc.subjectanaesthesiaen_US
dc.subjecttobacco smoke pollutionen_US
dc.titleThe effect of environmental tobacco smoke on the dose requirements of rocuronium in childrenen_US
dc.typeArticleen_US

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