Pharmacological, phytochemical and in-vivo toxicological perspectives of a xero-halophyte medicinal plant: Zaleya pentandra (L.) Jeffrey
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PERGAMON-ELSEVIER SCIENCE LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study endeavours to investigate the phytochemical composition, biological properties and in vivo toxicity of methanol and dichloromethane extracts of Zaleya pentandra (L.) Jeffrey. Total bioactive contents, antioxidant (phosphomolybdenum and metal chelating, DPPH, ARTS, FRAP and CUPRAC) and enzyme inhibition (cholinesterases, tyrosinase alpha-amylase, and alpha-glucosidase) potential were assessed utilizing in vitro bioassays. UHPLC-MS phytochemical profiling was carried out to identify the essential compounds. The methanol extract was found to contain highest phenolic (22.60 mg GAE/g) and flavonoid (31.49 mg QE/g) contents which correlate with its most significant radical scavenging, reducing potential and tyrosinase inhibition. The dichloromethane extract was most potent for phosphomolybdenum, ferrous chelation, alpha-amylase, alpha-glucosidase, and cholinesterase inhibition assays. UHPLC-MS analysis of methanol extract unveiled to identify 11 secondary metabolites belonging to five sub-groups, i.e., phenolic, alkaloid, carbohydrate, terpenoid, and fatty acid derivatives. Additionally, in vivo toxicity was conducted for 21 days and the methanol extract at different doses (150, 200, 250 and 300 mg/kg) was administered in experimental chicks divided into five groups each containing five individuals. Different physical, haematological and biochemical parameters along with the absolute and relative weight of visceral body organs were studied. Overall, no toxic effect was noted for the extract at tested doses.
Açıklama
1st International Conference on Natural Toxicology and Pharmacology (ICNTP) -- AUG 08-12, 2019 -- Guangzhou, PEOPLES R CHINA
Anahtar Kelimeler
Antioxidant, Bioactive contents, Enzyme inhibition, Toxicity Zaleya pentandra
Kaynak
FOOD AND CHEMICAL TOXICOLOGY
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
131
Sayı
Künye
Saleem, H., Zengin, G., Locatelli, M., Ahmad, I., Khaliq, S., Mahomoodally, M. F., Hussain, R., Rengasamy, K. R. R., Mollica, A., Zainal Abidin, S. A. Ahemad, N. (2019). Pharmacological, Phytochemical and In-Vivo Toxicological Perspectives of a Xero-Halophyte Medicinal Plant: Zaleya Pentandra (L.) Jeffrey. Food and Chemical Toxicology, 131, 110535.
