Effect of zinc deficiency and supplementation on lipid peroxidation of renal tissue in ovariectomized rats

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dc.contributor.authorBaltaci, AK
dc.contributor.authorSunar, F
dc.contributor.authorMogulkoc, R
dc.contributor.authorOztekin, E
dc.date.accessioned2020-03-26T16:48:22Z
dc.date.available2020-03-26T16:48:22Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate how zinc deficiency and supplementation affects lipid peroxidation in the renal tissue in ovariectomized rats. Four study groups were formed with 10 Spraque-Dawley rats each. Two of the groups served as normal and ovariectomized controls; the other two were ovariectomized rats that were zinc deficient and zinc supplemented, respectively. The zinc-deficient ovariectomized rats showed greater renal and plasma lipid peroxidation, as indicated by higher malondialdehyde levels than all other groups (p<0.05). These values were higher in the ovariectomized controls than those of the normal controls and of the ovariectomized, zinc-supplemented groups (p<0.05), which, in, turn, showed no significant differences of their respective renal and plasma malondialdehyde values. The renal and erythrocyte glutathione levels in the zinc-supplemented rats were higher than those in all other groups (p<0.05). The zinc-deficient group had the lowest renal and erythrocyte glutathione levels (p<0.05). The renal tissue zinc levels in the ovariectomized rats were higher than those in the zinc-deficient animals, but lower than in the normal controls and zinc-supplemented rats (p<0.05). The zinc-supplemented animals had the highest renal tissue zinc levels (p<0.05). The results of this study suggest that zinc deficiency increases renal tissue damage in ovariectomized rats and that zinc supplementation can be used to prevent this condition.en_US
dc.identifier.doi10.1385/BTER:101:3:231en_US
dc.identifier.endpage239en_US
dc.identifier.issn0163-4984en_US
dc.identifier.issue3en_US
dc.identifier.pmid15564653en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage231en_US
dc.identifier.urihttps://dx.doi.org/10.1385/BTER:101:3:231
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19023
dc.identifier.volume101en_US
dc.identifier.wosWOS:000225278800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHUMANA PRESS INCen_US
dc.relation.ispartofBIOLOGICAL TRACE ELEMENT RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectovariotomyen_US
dc.subjectzinc deficiency and supplementationen_US
dc.subjectmalondialdehydeen_US
dc.subjectglutathioneen_US
dc.titleEffect of zinc deficiency and supplementation on lipid peroxidation of renal tissue in ovariectomized ratsen_US
dc.typeArticleen_US

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