Regressive Course of Oxalate Deposition in Primary Hyperoxaluria After Kidney Transplantation

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dc.contributor.authorÇelik, Gülperi
dc.contributor.authorŞen, Sait
dc.contributor.authorSipahi, Savaş
dc.contributor.authorAkkın, Cezmi
dc.contributor.authorTamsel, S.
dc.contributor.authorToz, Hüseyin
dc.contributor.authorHoşcoşkun, C.
dc.date.accessioned2020-03-26T18:04:54Z
dc.date.available2020-03-26T18:04:54Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPrimary hyperoxaluria (PH) is a rare autosomal recessive disease caused by the functional defect of alanine-glyoxylate aminotransferase (AGT) enzyme in the liver and it is characterized by the deposition of diffuse calcium oxalate crystals. A 38-year-old male patient presented with history of recurrent nephrolithiasis and has received chronic hemodialysis treatment for 2 years. Cadaveric renal transplantation was applied to the case. The patient was reoperated on postoperative day 13 because of the collection surrounding the urethra. During this operation, kidney biopsy was made due to late decrease in creatinine levels. Deposition of diffuse oxalate crystal was detected in allograft kidney biopsy, whereas in the 0-hour biopsy there were no oxalate crystals. Oxalate level was found to be high in a 24-hour urine specimen (118 mg/L, normal level: 7-44 mg/L). The patient was identified with primary hyperoxaluria and followed up in terms of systemic oxalate deposition as well as allograft kidney. In the kidney biopsy taken after 18 months, we detected that oxalate crystals almost entirely disappeared. In our case, bilateral preretinal, intraretinal, and intravascular diffuse oxalate crystals were detected, and argon laser photocoagulation treatments were needed for choroidal and retinal neovascularization. Repeated ophthalmic examinations showed the regressive nature of oxalate depositions. In the 18th month, fundus examination and fluorescein angiography revealed that oxalate crystals were significantly regressed. To increase the quality of life and slow down the systemic effects of oxalosis, kidney-only transplantation is beneficial.en_US
dc.identifier.citationÇelik, G., Sen, S., Sipahi, S., Akkin, C., Tamsel, S., Toz, H., Hoşcoşkun, C., (2010). Regressive Course of Oxalate Deposition in Primary Hyperoxaluria After Kidney Transplantation. Renal Failure, 32(9), 1131-1136. Doi: 10.3109/0886022X.2010.509900
dc.identifier.doi10.3109/0886022X.2010.509900en_US
dc.identifier.endpage1136en_US
dc.identifier.issn0886-022Xen_US
dc.identifier.issue9en_US
dc.identifier.pmid20863224en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1131en_US
dc.identifier.urihttps://dx.doi.org/10.3109/0886022X.2010.509900
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25208
dc.identifier.volume32en_US
dc.identifier.wosWOS:000283121700021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇelik, Gülperi
dc.institutionauthorSen, S.
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPrimary hyperoxaluriaen_US
dc.subjectRenal transplantationen_US
dc.subjectKidney biopsyen_US
dc.subjectOxalate crystalsen_US
dc.subjectRetinal examinationen_US
dc.titleRegressive Course of Oxalate Deposition in Primary Hyperoxaluria After Kidney Transplantationen_US
dc.typeArticleen_US

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