The effect of pinealectomy and zinc deficiency on nitric oxide levels in rats with induced Toxoplasma gondii infection

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dc.contributor.authorBaltaci, AK
dc.contributor.authorMogulkoc, R
dc.contributor.authorTurkoz, Y
dc.contributor.authorBediz, CS
dc.contributor.authorOzugurlu, F
dc.date.accessioned2020-03-26T16:55:32Z
dc.date.available2020-03-26T16:55:32Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPrinciples: This study aims at investigating how zinc deficiency and pinealectomy affect nitric oxide levels in rats infected by Toxoplasma gondii. Methods: The study was conducted on a total of 50 adult, male rats of Spraque-Dawley species. The study groups were as follows: General, intact control group (Group I, n = 10), infected control group (Group II, n = 10), infected and zinc-deficient group (Group III, n = 10), infected and pincalectomized group (Group IV, n = 10), infected, zinc-deficient and pinealectomized group (Group V, n = 10). After the experiment the rats were decapitated and levels of zinc, melatonin and total nitrite were identified in the blood samples collected. Results: The total nitrite levels in groups TV and V were more than those in all other groups (p <0.01). The total nitrite levels in Group II were also higher than those in Groups I and III (p <0.01). Plasma zinc levels in the zinc-deficient group and zinc-deficient and pinealectomized group were lower than those in all other groups, while melatonin levels were lower in Infected pinealectomized group (Group IV) and infected, zinc-deficient and pinealectomized group (Group V) than all others (p <0.01). Conclusions: The present study shows that plasma nitric oxide levels increase during Toxoplasma gondii infection, but this increase becomes more apparent in the presence of melatonin deficiency and is inhibited by zinc deficiency.en_US
dc.identifier.endpage363en_US
dc.identifier.issn1424-7860en_US
dc.identifier.issue23-24en_US
dc.identifier.pmid15318286en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage359en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19234
dc.identifier.volume134en_US
dc.identifier.wosWOS:000222806500005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE M H SWISS MEDICAL PUBLISHERS LTDen_US
dc.relation.ispartofSWISS MEDICAL WEEKLYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectToxoplasma gondiien_US
dc.subjectzinc deficiencyen_US
dc.subjectpinealectomyen_US
dc.subjectnitric oxideen_US
dc.titleThe effect of pinealectomy and zinc deficiency on nitric oxide levels in rats with induced Toxoplasma gondii infectionen_US
dc.typeArticleen_US

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