Nonsurgical periodontal therapy with/without diode laser modulates metabolic control of type 2 diabetics with periodontitis: a randomized clinical trial

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dc.contributor.authorKocak, Emrah
dc.contributor.authorSaglam, Mehmet
dc.contributor.authorKayis, Seyit Ali
dc.contributor.authorDundar, Niyazi
dc.contributor.authorKebapcilar, Levent
dc.contributor.authorLoos, Bruno G.
dc.contributor.authorHakki, Sema S.
dc.date.accessioned2020-03-26T19:25:22Z
dc.date.available2020-03-26T19:25:22Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn order to evaluate whether nonsurgical periodontal treatment with/without diode laser (DL) decontamination improves clinical parameters, the levels of IL-1 beta, IL-6, IL-8, intercellular adhesion molecule (ICAM), and vascular cell adhesion molecule (VCAM) in gingival crevicular fluid and metabolic control (HbA1c) in chronic periodontitis (CP) patients with diabetes mellitus type 2 (DM2). Sixty patients with DM2 and CP were randomly assigned into two groups to receive scaling and root planing (SRP, n = 30) or SRP followed by diode laser application (SRP + DL, n = 30). Clinical periodontal and gingival crevicular fluid (GCF) parameters were assessed at baseline, 1, and 3 months after periodontal treatment. HbA1c levels were evaluated at baseline and 3 months post-therapy. Total amounts of cytokines and molecules were analyzed by ELISA. Nonsurgical periodontal treatment with/without DL appeared to improve clinical, biochemical parameters, and glycemic control in DM2 patients (BMI < 25 kg/m(2)) with CP. The SRP + DL group provided better reductions in probing depth (PD) and clinical attachment level (CAL) parameters compared to the SRP group (P < 0.05). Significant reductions were found in the total amounts of GCF levels of IL-1, IL-6, IL-8, ICAM, and VCAM after treatment (P < 0.05). HbA1c levels decreased significantly at 3 months after treatment (P < 0.05). SRP + DL reduced HbA1c levels more significantly compared to SRP alone (0.41 vs. 0.22 %, P < 0.05). SRP, especially in combination with DL, shows improvement of glycemic control for DM2 patients with CP.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [11202014]; Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK/SBAG-114S229]; University of Amsterdamen_US
dc.description.sponsorshipThe authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article. This study was supported by the Research Project Coordination of Selcuk University (project no. 11202014) and The Scientific and Technological Research Council of Turkey (TUBITAK/SBAG-114S229). Author BGL is supported in part by a grant of the University of Amsterdam (focal point "Oral Infections and Inflammation").en_US
dc.identifier.doi10.1007/s10103-016-1868-0en_US
dc.identifier.endpage353en_US
dc.identifier.issn0268-8921en_US
dc.identifier.issn1435-604Xen_US
dc.identifier.issue2en_US
dc.identifier.pmid26754181en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage343en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10103-016-1868-0
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33833
dc.identifier.volume31en_US
dc.identifier.wosWOS:000369330600018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER LONDON LTDen_US
dc.relation.ispartofLASERS IN MEDICAL SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiode lasersen_US
dc.subjectChronic periodontitisen_US
dc.subjectNonsurgical periodontal debridementen_US
dc.subjectDiabetes mellitusen_US
dc.subjectMetabolic controlen_US
dc.subjectCytokinesen_US
dc.subjectCell adhesion moleculesen_US
dc.titleNonsurgical periodontal therapy with/without diode laser modulates metabolic control of type 2 diabetics with periodontitis: a randomized clinical trialen_US
dc.typeArticleen_US

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