The effects of spironolactone on atrial remodeling in patients with preserved left ventricular function after an acute myocardial infarction: a randomized follow-up study

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dc.contributor.authorKayrak, Mehmet
dc.contributor.authorBacaksiz, Ahmet
dc.contributor.authorVatankulu, Mehmet A.
dc.contributor.authorAyhan, Selim S.
dc.contributor.authorAri, Hatem
dc.contributor.authorKaya, Zeynettin
dc.contributor.authorOzdemir, Kurtulus
dc.date.accessioned2020-03-26T18:05:17Z
dc.date.available2020-03-26T18:05:17Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives Atrial remodeling is an important part of cardiac remodeling after acute myocardial infarction (AMI). The aim of this study was to evaluate the effect of spironolactone on atria in patients with preserved left ventricular (LV) functions after AMI by using two-dimensional and tissue Doppler imaging techniques (TDI). Methods The study consisted of 110 patients with AMI, successfully revascularized with percutaneous coronary intervention, ejection fraction greater than or equal to 40%, and Killip class I-II. Patients were randomized into two groups: conventional therapy (n=55) and additional spironolactone of 25 mg/day with standard conventional therapy (n=55). Echocardiography was performed in the first 48-72 h of AMI and during 6 months of follow-up. Left atrial volume index and emptying fraction were obtained. The peak regional atrial contraction velocity, the time between the onset of p-wave on the monitor ECG and the onset, peak, and the end (TE) of the atrial contraction wave on the tissue Doppler technique curve were measured. Results The left atrial volume index and left atrium (LA) dimensions did not significantly change in either group. In the spironolactone group, left atrial emptying fraction increased compared with both baseline value ( from 53.0 +/- 0.16 to 57.0 +/- 0.13 P = 0.011) and conventional therapy group (from 50.0 +/- 0.17 to 47.0 +/- 0.16, P = 0.013). The atrial contraction velocity did not change but the LA-TE, interatrial septum-TE, and right atrium-TE were prolonged in the conventional therapy group. Conclusion Additional spironolactone therapy provided a little benefit on LA remodeling and atrial electromechanic properties in patients with AMI and preserved LV functions. Coron Artery Dis 21:477-485 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.en_US
dc.identifier.doi10.1097/MCA.0b013e32833fd243en_US
dc.identifier.endpage485en_US
dc.identifier.issn0954-6928en_US
dc.identifier.issn1473-5830en_US
dc.identifier.issue8en_US
dc.identifier.pmid20926948en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage477en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MCA.0b013e32833fd243
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25374
dc.identifier.volume21en_US
dc.identifier.wosWOS:000284150800007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofCORONARY ARTERY DISEASEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectechocardiographyen_US
dc.subjectmyocardial infarctionen_US
dc.subjectspironolactoneen_US
dc.subjectventricular remodelingen_US
dc.titleThe effects of spironolactone on atrial remodeling in patients with preserved left ventricular function after an acute myocardial infarction: a randomized follow-up studyen_US
dc.typeArticleen_US

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