Alterations of blood parameters after intramuscular administration of imidocarb in healthy lambs

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dc.contributor.authorEkici, Ozlem Derinbay
dc.contributor.authorIsik, Nermin
dc.date.accessioned2020-03-26T18:23:45Z
dc.date.available2020-03-26T18:23:45Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the safety of imidocarb dipropionate in sheep. Imidocarb dipropionate (IMDP) was administered (2.4 mg/kg, intramuscular; i.m.) to 10 sheep, and blood samples were obtained 0, 1, 6, and 9 days after treatment. Hemacell counts, serum biochemical values, coagulation values, and serum oxidative status were measured. IMDP caused transient decreases in pH, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, lactate dehydrogenase, and retinol levels and transient increases in serum creatine kinase-MB, blood urea nitrogen, and creatinine levels. IMDP decreased adenosine deaminase activity, antithrombin III, and superoxide dismutase activity and increased white blood cell counts. In conclusion, IMDP may change serum oxidative status and cause coagulation disorders during treatment in sheep.en_US
dc.identifier.doi10.3109/01480545.2011.589449en_US
dc.identifier.endpage166en_US
dc.identifier.issn0148-0545en_US
dc.identifier.issn1525-6014en_US
dc.identifier.issue2en_US
dc.identifier.pmid21834689en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage162en_US
dc.identifier.urihttps://dx.doi.org/10.3109/01480545.2011.589449
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27719
dc.identifier.volume35en_US
dc.identifier.wosWOS:000300451900007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofDRUG AND CHEMICAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectImidocarb dipropionateen_US
dc.subjectsafetyen_US
dc.subjectlamben_US
dc.titleAlterations of blood parameters after intramuscular administration of imidocarb in healthy lambsen_US
dc.typeArticleen_US

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