Prevention of Renal Damage by Alpha Tocopherol in Ischemia and Reperfusion Models of Rats

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dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorYurdakul, Talat
dc.contributor.authorErdemli, Esra
dc.contributor.authorYavuz, Ayşe
dc.date.accessioned2020-03-26T16:45:59Z
dc.date.available2020-03-26T16:45:59Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIschemia-reperfusion injury in rat kidneys most probably comes from oxidative stress, but the possible preventive effect of alpha-tocopherol (AT) treatment on this injury has not yet been established. Forty male Wistar rats were randomly divided into four groups. The left renal arteries of all rats except the controls were clamped to induce renal ischemia. The left kidneys of the rats in the ischemia group were removed following 40 min ischemia. The rats in the ischemia-reperfusion and ischemia-reperfusion-AT groups were treated similarly, but in these groups the renal arteries were re-perfused for 1 h following ischemia. The rats in the ischemia-reperfusion-AT group also received 10 mg/kg AT 3 h prior to ischemia. The specimens were examined histopathologically and ultrastructurally, and the tissue calcium levels were measured. Light microscope and ultrastructural examination showed that the greatest damage occurred in the ischemia-reperfusion group. The highest level of tissue calcium was also found in this group. In the ischemia-reperfusion-AT-treated group, less tissue damage and a lower tissue calcium concentration was found compared to both the ischemia and ischemia-reperfusion groups. Our results indicate that AT can reduce tissue damage after ischemia-reperfusion injury.en_US
dc.identifier.citationAvunduk, M. C., Yurdakul, T., Erdemli, E., Yavuz, A., (2003). Prevention of Renal Damage by Alpha Tocopherol in Ischemia and Reperfusion Models of Rats. Urological Research, (31), 280-285. Doi: 10.1007/s00240-003-0329-y
dc.identifier.doi10.1007/s00240-003-0329-yen_US
dc.identifier.endpage285en_US
dc.identifier.issn0300-5623en_US
dc.identifier.pmid12844243en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage280en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00240-003-0329-y
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18537
dc.identifier.volume31en_US
dc.identifier.wosWOS:000184902700011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAvunduk, Mustafa Cihat
dc.institutionauthorYurdakul, Talat
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofUrological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectİschemiaen_US
dc.subjectReperfusionen_US
dc.subjectAlpha-Tocopherolen_US
dc.subjectRenal Artery Clampingen_US
dc.subjectRaten_US
dc.titlePrevention of Renal Damage by Alpha Tocopherol in Ischemia and Reperfusion Models of Ratsen_US
dc.typeArticleen_US

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