Protective effects of growth hormone on bacterial translocation and intestinal damage in rats with partial intestinal obstruction

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dc.contributor.authorKaymakcı, Aytekin
dc.contributor.authorGüven, Şirin
dc.contributor.authorÇiftçi, İlhan
dc.contributor.authorAkıllıoğlu, İshak
dc.contributor.authorAktan, Murad
dc.contributor.authorEker, Hasan Hüseyin
dc.contributor.authorSütçü, A.
dc.date.accessioned2020-03-26T18:58:26Z
dc.date.available2020-03-26T18:58:26Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: One of the reasons of bacterial translocation (BT) is the complete or partial intestinal obstructions (PIO) of the gastrointestinal system. In this study, we aimed to investigate the effects of recombinant human Growth Hormone (rhGH) on BT in rats with partial intestinal obstruction (PIO). Material and methods: The rats were randomly divided into the 4 groups: Group I: Sham-operated (SO) (n = 12), Group II control PIO (n = 12), Group III: PIO with rhGH treatment for 5 days (n = 12), Group IV: PIO with rhGH treatment 5 days before PIO and 5 days after PIO (a total of 10 days) (n = 12). In the groups III and IV, the effects of 5 and 10 days administered rhGH were examined. Results: The level of serum and of intestinal fluid IgA was significantly higher in the Group IV compared to the Group I, Group II and Group III. In the Group IV, the number of small intestinal goblet and colonic goblet cells, and the lengths of intestinal mucosal villi and crypt depths were statistically significantly higher than in Groups II and III. The rate of bacterial translocation was higher in the Group II: 100 % in MLNs, 41.6 % in blood culture and 50.8 % in the liver cultures, it was significantly higher compared to the other groups (p < 0.01). Conclusions: The study results demonstrated that administration of rhGH to the rats with PIO for at least 10 days decreased bacterial translocation (Fig. 3, Ref. 25). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2014_078en_US
dc.identifier.endpage399en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue7en_US
dc.identifier.pmid25077360en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage395en_US
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2014_078
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31096
dc.identifier.volume115en_US
dc.identifier.wosWOS:000340863400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbacterial translocationen_US
dc.subjectpartial intestinal obstructionen_US
dc.subjectraten_US
dc.subjectrecombinant human Growth Hormoneen_US
dc.subjectmesenteric lymph ganglionen_US
dc.titleProtective effects of growth hormone on bacterial translocation and intestinal damage in rats with partial intestinal obstructionen_US
dc.typeArticleen_US

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