The effects of folic acid in the prevention of neural tube development defects caused by phenytoin in early chick embryos

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dc.contributor.authorGüney, Önder
dc.contributor.authorCanbilen, Aydan
dc.contributor.authorKonak, Abdullah
dc.contributor.authorAcar, Osman
dc.date.accessioned2020-03-26T16:46:12Z
dc.date.available2020-03-26T16:46:12Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractStudy Design. The effects of phenytoin and folic acid on the the development of neural tube defects in early chick embryos were studies. Objective. To investigate the effects of folic acid in the prevention of neural tube development defects. Summary of Background Data. Several studies have shown that phenytoin selectively inhibits neural tube closure. Folic acid supplementation has been reported to decrease the occurrence of neural tube defects. Methods. This study shows the effects of folic acid in preventing neural tube development defects caused by phenytoin in chicks based on light microscopy, transmission electron microscopy, and histopathological examination. Forty-five fertile Hubbard Broil eggs, all at Stage 8 (four somite) of development, were divided into three equal groups: Group 1 embryos (n = 15), the control group, were explanted and grown for 18 hours in a nutrient medium (thin albumin). Group 2 embryos (n = 15) were explanted and grown for 18 hours in a nutrient medium containing 500 mug/mL of phenytoin. Group 3 embryos (n = 15) were explanted and grown for 18 hours in a nutrient medium containing 500 mug/mL of phenytoin and 0.4 mug/mL of folic acid. Results. After the incubation period, 86.6% of the control embryos (Group 1) had intact neural tubes; 80% of Group 2 and 46.6% of Group 3 embryos showed neural tube defects. Conclusions. The results of this study suggest that phenytoin causes neural tube defects, whereas folic acid decreases the incidence of neural tube development defects caused by phenytoin in early chick embryos.en_US
dc.identifier.doi10.1097/00007632-200303010-00006en_US
dc.identifier.endpage445en_US
dc.identifier.issn0362-2436en_US
dc.identifier.issue5en_US
dc.identifier.pmid12616154en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage442en_US
dc.identifier.urihttps://dx.doi.org/10.1097/00007632-200303010-00006
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18593
dc.identifier.volume28en_US
dc.identifier.wosWOS:000181418200005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofSPINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectfolic aciden_US
dc.subjectearly chick embryoen_US
dc.subjectneural tube defecten_US
dc.subjectphenytoinen_US
dc.titleThe effects of folic acid in the prevention of neural tube development defects caused by phenytoin in early chick embryosen_US
dc.typeArticleen_US

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