Transferrin receptor in proliferation of T lymphocytes in infants with iron deficiency

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dc.contributor.authorArtac, H.
dc.contributor.authorCoskun, M.
dc.contributor.authorKaradogan, I.
dc.contributor.authorYegin, O.
dc.contributor.authorYesilipek, A.
dc.date.accessioned2020-03-26T17:18:41Z
dc.date.available2020-03-26T17:18:41Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to contribute to clarify the mechanism of cellular immune insufficiency occurring during iron deficiency. We studied the expression of the transferrin receptor (TfR) which is called as CD71, on the surface of T lymphocytes in infants with iron deficiency (with and without anemia). A total of 33 infants, aged between 7 and 26 months were included in this study. These subjects were divided into three groups: (i) latent iron deficiency (LID) (group 1), (ii) iron deficiency anemia (IDA) (group 2), and (iii) healthy infants (group 3). Both CD3 levels and CD71 expression of T lymphocytes were analysed by flow cytometry before and after phytohaemagglutinin (PHA) stimulation. The percentage of CD3(+) lymphocytes in infants with IDA was lower than that in controls after PHA stimulation (mean +/- SD, 48.6 +/- 10.5%vs. 70.7 +/- 7.8%, P < 0.001). The TfR expression of T lymphocytes (CD3 + CD71%) increased in all three groups after PHA stimulation (P < 0.001). No significant difference was seen among the three groups with respect to CD3 + CD71%. Although there was a reduction in the proliferative capacity of T lymphocytes in infants with IDA, their ability to express transferrin receptor on T-lymphocyte cell surface was normal.en_US
dc.identifier.doi10.1111/j.1365-2257.2006.00848.xen_US
dc.identifier.endpage315en_US
dc.identifier.issn1751-5521en_US
dc.identifier.issue4en_US
dc.identifier.pmid17617082en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage310en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1365-2257.2006.00848.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21717
dc.identifier.volume29en_US
dc.identifier.wosWOS:000247817200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBLACKWELL PUBLISHINGen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectiron deficiencyen_US
dc.subjectinfanten_US
dc.subjectT lymphocyteen_US
dc.subjecttransferrin receptoren_US
dc.titleTransferrin receptor in proliferation of T lymphocytes in infants with iron deficiencyen_US
dc.typeArticleen_US

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