Single dose of tiotropium improves the 6-minute walk distance in chronic obstructive pulmonary disease

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dc.contributor.authorOkudan, Nilsel
dc.contributor.authorGok, Mehmet
dc.contributor.authorGokbel, Hakki
dc.contributor.authorSuerdem, Mecit
dc.date.accessioned2020-03-26T17:04:19Z
dc.date.available2020-03-26T17:04:19Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.descriptionExperimental Biology 2005 Meeting/35th International Congress of Physiological Sciences -- MAR 31-APR 06, 2005 -- San Diego, CAen_US
dc.description.abstractThe aim of this study was to evaluate the effect of a single dose of tiotropium on the exercise capacity of stable chronic obstructive pulmonary disease (COPD) patients. The study was a randomized, placebo-controlled, double-blind, cross-over study. Forty-four stable COPD patients with moderate to severe airway obstruction were selected according to the GOLD criteria. The regular anticholinergic therapies of the patients were interrupted one week before the test. In the morning hours of the first day, half the group was given one capsule (18 mcg) of tiotropium and the other half was given placebo as inhalation using the HandiHaler (R) device. Before and 120 min after the medication, the 6-min walk test was performed * Oxygen saturation, modified Borg dyspnea ratings, blood pressure, and heart rate were recorded before and after the test. The same procedure was repeated at the same time on the third day but this time the patients were given placebo if they used tiotropium on the first day and vice versa. Before using tiotropium or placebo there was no difference between 6-min walk distances. The 6-min walk distance after the use of tiotropium (429.3 +/- 70.6 m) was significantly longer than that after the use of placebo (414.7 +/- 74.6 m). The changes in Borg dyspnea ratings and arterial oxygen saturation values with tiotropium and placebo use were not significant. We conclude that exercise capacity might be improved by using a single-dose tiotropium inhalation in moderate to severe COPD patients.en_US
dc.description.sponsorshipAmer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Expt Therapeut, Int Union Physiol Scien_US
dc.identifier.doi10.1007/s00408-005-2582-zen_US
dc.identifier.endpage204en_US
dc.identifier.issn0341-2040en_US
dc.identifier.issue4en_US
dc.identifier.pmid17006746en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00408-005-2582-z
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20675
dc.identifier.volume184en_US
dc.identifier.wosWOS:000239961100002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofLUNGen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectchronic obstructive pulmonary diseaseen_US
dc.subjectwalking testen_US
dc.subjecttiotropiumen_US
dc.subjectexercise toleranceen_US
dc.subjectexercise testingen_US
dc.titleSingle dose of tiotropium improves the 6-minute walk distance in chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US

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