Is there any relationship between metabolic parameters and left ventricular functions in type 2 diabetic patients without evident heart disease?

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dc.contributor.authorYazici, Mehmet
dc.contributor.authorOzdemir, Kurtulus
dc.contributor.authorGonen, Mustafa Sait
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorUlgen, Mehmet Siddik
dc.contributor.authorDuzenli, Mehmet Akif
dc.contributor.authorYazici, Raziye
dc.date.accessioned2020-03-26T17:27:08Z
dc.date.available2020-03-26T17:27:08Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The aim of the present study was to evaluate left ventricle (LV) systolic and diastolic function, using tissue Doppler echocardiography (TDE) and color M-mode flow propagation velocity, in relation to blood glucose status in normotensive patients with type 2 diabetes mellitus (T2DM) who had no clinical evidence of heart disease. Methods: Seventy-two patients with T2DM (mean age 49.1 +/- 9.8 years) without symptoms, signs or history of heart disease and hypertension, and 50 ages matched healthy controls (mean age 46.1 +/- 9.8 years) had echocardiography. Systolic and diastolic LV functions were detected by using conventional echocardiography, TDE and mitral color M-mode flow propagation velocity (V-E). Fasting blood glucose level (FBG) after 8 hours since eating a meal, postprandial blood glucose level (PPG), and HbA(1C) level were determined. The association of FBG, PPG and HbA(1C) with the echocardiographic parameters was investigated. Results: It was detected that although systolic functions of two groups were similar, diastolic functions were significantly impaired in diabetics. No relation of FBG and PPG with systolic and diastolic functions was determined. However, HbA(1C) was found to be related to diastolic parameters such as E/A, Em/Am, V-E and E/V-E (beta = -0.314, P = < 0.05; beta = -0.230, P < 0.05; beta = -0.602, P < 0.001, beta = 0.387, P < 0.005, respectively). In addition to HbA(1C), LV, diastolic functions were also correlated with age and diabetes duration. Conclusion: Diastolic LV dysfunction may develop even in absence of ischemia, hypertension, and LVH in T2DM. FBG and PPG have no effect on LV functions, but HbA(1C) levels may affect diastolic parameters.en_US
dc.identifier.doi10.1111/j.1540-8175.2008.00690.xen_US
dc.identifier.endpage682en_US
dc.identifier.issn0742-2822en_US
dc.identifier.issue7en_US
dc.identifier.pmid18445056en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage675en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1540-8175.2008.00690.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22482
dc.identifier.volume25en_US
dc.identifier.wosWOS:000258400000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBLACKWELL PUBLISHINGen_US
dc.relation.ispartofECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDoppler tissue imagingen_US
dc.subjectdiabetes mellitusen_US
dc.subjectleft ventricular functionen_US
dc.titleIs there any relationship between metabolic parameters and left ventricular functions in type 2 diabetic patients without evident heart disease?en_US
dc.typeArticleen_US

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