Both hypothyroidism and hyperthyroidism increase plasma irisin levels in rats

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dc.contributor.authorAtici, Emine
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorMenevse, Esma
dc.date.accessioned2020-03-26T19:53:01Z
dc.date.available2020-03-26T19:53:01Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: A recently discovered hormone, irisin is accepted to be significantly involved in the regulation of body weight. Thyroid functions may be, directly or indirectly, associated with irisin. Aim: The aim of the present study is to determine the effect of experimental thyroid dysfunction on irisin levels in rats. Methods: The study registered 40 adult male Sprague-Dawley rats, which were allocated to groups as follows: 1. Control; 2. Hypothyroidism induced by injection of 10 mg/kg/day intraperitoneal propylthiouracil (PTU) for 3 weeks; 3. Hypothyroidism (PTU 2 weeks) + L-thyroxin (1.5 mg/kg/day for 1 week); 4. Hyperthyroidism induced in rats by 3-week thyroxin (0.3 mg/kg/day); 5. Hyperthyroidism + PTU. At the end of the study, blood samples were collected to quantify free triiodothyronine (FT3), free triiodothyronine (FT4) and irisin levels. Results: FT3 and FT4 levels were reduced in hypothyroidism and were significantly elevated in hyperthyroidism (p < 0.001). Irisin values, on the other hand, were found to be elevated in both hypothyroidism and hyperthyroidism groups (p < 0.001). Conclusion: The results of the study suggest that irisin values increase in thyroid dysfunction, hypo-and hyperthyroidism, and that when hypothyroidism is corrected by thyroxin administration and hyperthyroidism by PTU injection, plasma irisin values go back to normal.en_US
dc.description.sponsorshipSelcuk University, Scientific Research CouncilSelcuk University [14202034]en_US
dc.description.sponsorshipThis study was supported by a grant Selcuk University, Scientific Research Council (Grant number is 14202034).en_US
dc.identifier.doi10.1515/hmbci-2017-0054en_US
dc.identifier.issn1868-1883en_US
dc.identifier.issn1868-1891en_US
dc.identifier.issue3en_US
dc.identifier.pmid29182513en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://dx.doi.org/10.1515/hmbci-2017-0054
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36374
dc.identifier.volume33en_US
dc.identifier.wosWOS:000428812600005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofHORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthyperthyroidismen_US
dc.subjecthypothyroidismen_US
dc.subjectirisinen_US
dc.subjectPTUen_US
dc.subjectthyroxineen_US
dc.titleBoth hypothyroidism and hyperthyroidism increase plasma irisin levels in ratsen_US
dc.typeArticleen_US

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