Effects of desflurane, sevoflurane and propofol on phagocytosis and respiratory burst activity of human polymorphonuclear leucocytes in bronchoalveolar lavage

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dc.contributor.authorErol, Atilla
dc.contributor.authorReisli, Ruhiye
dc.contributor.authorReisli, İsmail
dc.contributor.authorKara, Reyhan
dc.contributor.authorOtelcioğlu, Şeref
dc.date.accessioned2020-03-26T17:38:25Z
dc.date.available2020-03-26T17:38:25Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and objective In polymorphonuclear leucocytes, phagocytosis and respiratory burst activity are mainly responsible for bacterial killing. We aimed to investigate the effects of anaesthesia with desflurane, sevoflurane and propofol on these functional activities of polymorphonuclear leucocytes in bronchoalveolar lavage fluid. Methods Sixty patients scheduled to have tympanoplasty surgery were studied. The patients were divided into three groups (group D, desflurane; group S, sevoflurane; group P, propofol). Anaesthesia was induced with propofol, fentanyl and rocuronium in all groups. Anaesthesia was maintained with inhalation agent or propofol. Bronchoalveolar lavage was performed immediately after induction of anaesthesia and after surgical procedure by a fibreoptic bronchoscope. Leucocyte respiratory burst and phagocytic activity in bronchoalveolar lavage fluid were determined by flow cytometric analysis of gated leucocyte populations within 2 h after each bronchoalveolar lavage sample. Changes in leucocyte functions with time were expressed as mean fluorescence intensity. Results There were no significant differences in phagocytic activity of polymorphonuclear leucocytes within and between the groups. The respiratory burst function of polymorphonuclear leucocytes showed a significant increase after surgery in group P (P<0.05). When we compared the differences between the three groups, we found the difference in mean fluorescence intensity as statistically significant between group P and group S. Conclusion This study showed that propofol anaesthesia increased the respiratory burst function of polymorphonuclear leucocytes in bronchoalveolar lavage fluid. Eur J Anaesthesiol 26:150-154 (c) 2009 European Society of Anaesthesiology.en_US
dc.identifier.doi10.1097/EJA.0b013e328319bfeben_US
dc.identifier.endpage154en_US
dc.identifier.issn0265-0215en_US
dc.identifier.issn1365-2346en_US
dc.identifier.issue2en_US
dc.identifier.pmid19142090en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage150en_US
dc.identifier.urihttps://dx.doi.org/10.1097/EJA.0b013e328319bfeb
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23476
dc.identifier.volume26en_US
dc.identifier.wosWOS:000263088300012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofEUROPEAN JOURNAL OF ANAESTHESIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectanaesthetics inhalationen_US
dc.subjectanaesthetics intravenousen_US
dc.subjectbronchoalveolar lavageen_US
dc.subjectdesfluraneen_US
dc.subjectflow cytometryen_US
dc.subjectphagocytosisen_US
dc.subjectpropofolen_US
dc.subjectrespiratory burst activityen_US
dc.subjectsevofluraneen_US
dc.titleEffects of desflurane, sevoflurane and propofol on phagocytosis and respiratory burst activity of human polymorphonuclear leucocytes in bronchoalveolar lavageen_US
dc.typeArticleen_US

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