Cadmium and iron accumulation in rat lens after cigarette smoke exposure and the effect of vitamin E (alpha-tocopherol) treatment

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dc.contributor.authorAvunduk, AM
dc.contributor.authorYardimci, S
dc.contributor.authorAvunduk, MC
dc.contributor.authorKurnaz, L
dc.date.accessioned2020-03-26T16:27:02Z
dc.date.available2020-03-26T16:27:02Z
dc.date.issued1999
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose. Cadmium accumulation in the lens has been implicated in cataractogenesis of chronic smokers. This study was planned to evaluate whether or not in vivo cigarette smoke exposure causes cadmium accumulation in rat lens, and possible protective effect and mechanism of alpha-tocopherol (vitamin E) treatment on cataractogenesis. Methods. 28 male Wistar rats were randomly divided into four equal groups. Group 3 and 4 rats were exposed to cigarette smoke over ninety consecutive days, and Group 1 and 2 rats were treated in a similar fashion but exposed only to room air. Additionally, vitamin E was given to Group 2 and 4 rats. Results. Significantly higher iron levels were observed in the lenses of Group 3 rats compared to other groups. With respect to cadmium, Group 3 and 4 rats had significantly higher levels compared to Group 1 and 2 rats. Although vitamin E treatment prevented iron accumulation in Group 4 rats, it had no effect on cadmium concentrations. Distinct histopathological changes observed in Group 3 rats were not present in Group 4 rats. Conclusion. Our study demonstrates that in vivo cigarette smoke exposure causes accumulation of cadmium in rat lens and IM vitamin E treatment does not affect this accumulation. The protective effect of vitamin E treatment on smoke exposed rat lens seems to be mediated by blockage of iron accumulation in the lens.en_US
dc.identifier.doi10.1076/ceyr.18.6.403.5268en_US
dc.identifier.endpage407en_US
dc.identifier.issn0271-3683en_US
dc.identifier.issn1460-2202en_US
dc.identifier.issue6en_US
dc.identifier.pmid10435826en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage403en_US
dc.identifier.urihttps://dx.doi.org/10.1076/ceyr.18.6.403.5268
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16933
dc.identifier.volume18en_US
dc.identifier.wosWOS:000080989300002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofCURRENT EYE RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcadmiumen_US
dc.subjectcataracten_US
dc.subjectcigarette smokeen_US
dc.subjectraten_US
dc.subjectvitamin Een_US
dc.titleCadmium and iron accumulation in rat lens after cigarette smoke exposure and the effect of vitamin E (alpha-tocopherol) treatmenten_US
dc.typeArticleen_US

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