The impact of waist-to-hip ratio on clinical outcomes in metastatic breast cancer patients treated with aromatase inhibitors

Basit Öğe Kaydı
dc.contributor.authorArtaç, Mehmet
dc.contributor.authorBozcuk, Hakan
dc.contributor.authorAfacan, Berna
dc.contributor.authorÖzdoğan, Mustafa
dc.contributor.authorSamur, Mustafa
dc.date.accessioned2020-03-26T17:29:11Z
dc.date.available2020-03-26T17:29:11Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe aimed to identify whether abdominal fat distribution could affect the outcome in metastatic breast cancer (MBC) patients treated with aromatase inhibitors (AIs) or not. A total of 42 MBC patients treated with first line hormonal therapy were enrolled in this study. Factors associated with overall survival in the univariate analysis were age, c-erb-B2 expression intensity (+++ versus others by immunohistochemistry), and WHR, whereas only WHR retained significance in the multivariate analysis. Median overall survival figures were 472 days versus unreached for patients with a WHR of <0.92 and ?0.92 (Log rank statistic = 9.76, P = 0.002). Similarly, the corresponding progression free survival figures for patients with a WHR of <0.92 and ?0.92 were 423 versus 1004 days (Log rank statistic = 6.37, P = 0.012). This study suggests that WHR may serve as a potential predictive marker in MBC patients treated with AIs. © 2008 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.breast.2008.01.007en_US
dc.identifier.endpage422en_US
dc.identifier.issn0960-9776en_US
dc.identifier.issue4en_US
dc.identifier.pmid18455405en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage418en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.breast.2008.01.007
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22926
dc.identifier.volume17en_US
dc.identifier.wosWOS:000259711400017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofBreasten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAromatase inhibitorsen_US
dc.subjectBody fat distributionen_US
dc.subjectHormonotherapyen_US
dc.subjectMetastatic breast canceren_US
dc.subjectWaist-to-hip ratioen_US
dc.titleThe impact of waist-to-hip ratio on clinical outcomes in metastatic breast cancer patients treated with aromatase inhibitorsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu