Bone and Calcium Metabolism in Subclinical Autoimmune Hyperthyroidism and Hypothyroidism

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dc.contributor.authorKısakol, Gürcan
dc.contributor.authorKaya, Ahmet
dc.contributor.authorGönen, Sait
dc.contributor.authorTunç, Recep
dc.date.accessioned2020-03-26T16:45:28Z
dc.date.available2020-03-26T16:45:28Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBone turnover is reported to increase in favour of resorption in overt hyperthyroidism and the rate of resorption is associated with the levels of thyroid hormones. Hypothyroidism, on the other hand, was shown to cause no disturbance of calcium kinetics and found to associate lower trabecular resorption surfaces and increased bone cortical thickness. Similar studies are very rare in subclinical thyroid disorders and consequently we aimed to examine calcium and bone metabolism in subclinical thyroid disorders. Thirteen patients with subclinical hyperthyroidism secondary to untreated Graves' disease, 20 patients with subclinical hypothyroidism and 10 healthy subjects participated in this survey. Briefly calcium, phosphorus, and creatinine (Cre), urinary deoxypyridinoline (U-DPD) and serum osteocalcin (OC) were measured as biochemical markers for calcium metabolism. Concerning serum Ca and phosphorus levels, there were no differences between three of the groups, but urinary Ca excretion was higher in subclinical hyperthyroid patients compared to control and hypothyroid subjects. Hypothyroid patients had similar U-DPD levels with control subjects (p = 0.218). Serum OC and U-DPD were higher in subclinical hyperthyroid compared to control subjects (p<0.001 and p<0.001 respectively). We demonstrated a higher bone turnover and greater calcium excretion in subclinical hyperthyroid patients. Additionally, we found that subclinical hypothyroidism is not associated with disturbed calcium metabolism. As persistent increase in bone turnover is responsible for accelerated bone loss, patients with Graves' disease may have increased risk for osteoporosis.en_US
dc.identifier.citationKısakol, G., Kaya, A., Gönen, S., Tunç, R., (2003). Bone and Calcium Metabolism in Subclinical Autoimmune Hyperthyroidism and Hypothyroidism. Endocrine Journal, 50(6), 657-661. Doi: 10.1507/endocrj.50.657
dc.identifier.doi10.1507/endocrj.50.657en_US
dc.identifier.endpage661en_US
dc.identifier.issn0918-8959en_US
dc.identifier.issue6en_US
dc.identifier.pmid14709834en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage657en_US
dc.identifier.urihttps://dx.doi.org/10.1507/endocrj.50.657
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18381
dc.identifier.volume50en_US
dc.identifier.wosWOS:000187973400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKısakol, Gürcan
dc.institutionauthorKaya, Ahmet
dc.institutionauthorGönen, Sait
dc.institutionauthorTunç, Recep
dc.language.isoenen_US
dc.publisherJapan Endocrine Societyen_US
dc.relation.ispartofEndocrine Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSubclinical hyperthyroidismen_US
dc.subjectSubclinical hypothyroidismen_US
dc.subjectBone markersen_US
dc.subjectBone metabolismen_US
dc.subjectBone turnoveren_US
dc.titleBone and Calcium Metabolism in Subclinical Autoimmune Hyperthyroidism and Hypothyroidismen_US
dc.typeArticleen_US

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