Plasma-soluble urokinase plasminogen activator receptor (suPAR) levels in Behcet's disease and correlation with disease activity

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dc.contributor.authorKurtipek, Gülcan Saylam
dc.contributor.authorKesli, Recep
dc.contributor.authorAkyürek, Fatma Tunçez
dc.contributor.authorAkyürek, Fikret
dc.contributor.authorAtaseven, Arzu
dc.contributor.authorTerzi, Yüksel
dc.date.accessioned2020-03-26T19:55:11Z
dc.date.available2020-03-26T19:55:11Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackgroundSoluble urokinase plasminogen activator receptor (suPAR), a new biomarker, is a soluble form of membrane-bound receptors secreted from different immune cells. The aim of the present study is to determine plasma suPAR levels in Behcet's disease and their correlation with disease activity. MethodsThirty Behcet's disease patients determined according to the International Study Group criteria for Behcet's disease diagnosis and 41 healthy subjects were included in the present study. Micro-enzyme-linked immunosorbent assay was employed to obtain quantitative data. Data of both groups were statistically analyzed. ResultsThe comparison of C-reactive protein and suPAR plasma levels of the control and Behcet's disease group revealed statistically significant differences (respectively, P = 0.003 < 0.05 and P = 0.020 < 0.05). However, plasma suPAR levels related with disease activity revealed no statistically significant differences (P > 0.05). ConclusionThe present study is the first study analyzing suPAR levels in Behcet's disease patients and their correlation with disease activity. However, further prospective studies with larger patient series using suPAR as a new plasma biomarker are required to diagnose and monitor Behcet's disease and to support the findings of the present study.en_US
dc.description.sponsorshipKonya Training and Research Hospital-Education and Research Funden_US
dc.description.sponsorshipThe present study is supported financially by the Konya Training and Research Hospital-Education and Research Fund.en_US
dc.identifier.endpage870en_US
dc.identifier.issn1756-1841en_US
dc.identifier.issn1756-185Xen_US
dc.identifier.issue4en_US
dc.identifier.pmid27171829en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage866en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36868
dc.identifier.volume21en_US
dc.identifier.wosWOS:000429000500012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF RHEUMATIC DISEASESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBehcet's diseaseen_US
dc.subjectC-reactive proteinen_US
dc.subjectinflammationen_US
dc.subjectsuPARen_US
dc.titlePlasma-soluble urokinase plasminogen activator receptor (suPAR) levels in Behcet's disease and correlation with disease activityen_US
dc.typeArticleen_US

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