Effect of Ankaferd blood stopper (R) on tendon healing: an experimental study in a rat model of Achilles tendon injury

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dc.contributor.authorAydin, Bahattin Kerem
dc.contributor.authorAltan, Egemen
dc.contributor.authorAcar, Mehmet Ali
dc.contributor.authorErkocak, Omer Faruk
dc.contributor.authorUgras, Serdar
dc.date.accessioned2020-03-26T19:02:02Z
dc.date.available2020-03-26T19:02:02Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: This in vivo study aims to investigate the effects of Ankaferd Blood Stopper (R) (ABS) which is a recently developed topical hemostatic agent on tendon healing using a rat Achilles tendon injury model. Materials and methods: Twelve male Wistar-Albino rats were used in the study. Right legs of the rats were assigned as the study group, and left legs were assigned as the control group. Under anesthesia, bilateral Achilles tendon injuries were created and repaired surgically. To the surgical sites, 1 mL of ABS for the right side and 1 mL of serum physiologic solution for the left side were applied. Animals were euthanized on the 21st postoperative day, and tendon samples were collected from the extremities. Histological analyses were performed according to the semiquantitative tendon scoring system (Bonar Scale). Results: Total tendon healing scores were significantly poorer in the study group compared to the control group. Although there were no significant differences between the groups in terms of tenocyte morphology, degree of ground substance staining, and vascularity, the collagen morphology scores were significantly poorer in the study group. Conclusion: In our study, application of ABS had histologically negative effect on tendon healing in rats. However, further biomechanical and immune histochemical studies are required to support these results.en_US
dc.identifier.doi10.5606/ehc.2015.08en_US
dc.identifier.endpage37en_US
dc.identifier.issn1305-8282en_US
dc.identifier.issn1309-0313en_US
dc.identifier.issue1en_US
dc.identifier.pmid25741918en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://dx.doi.org/10.5606/ehc.2015.08
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32032
dc.identifier.volume26en_US
dc.identifier.wosWOS:000351408800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTURKISH JOINT DISEASES FOUNDATIONen_US
dc.relation.ispartofEKLEM HASTALIKLARI VE CERRAHISI-JOINT DISEASES AND RELATED SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAchilles tendonen_US
dc.subjectAnkaferd Blood Stopperen_US
dc.subjecthemorrhageen_US
dc.subjecthemostasisen_US
dc.subjecttendon injuriesen_US
dc.titleEffect of Ankaferd blood stopper (R) on tendon healing: an experimental study in a rat model of Achilles tendon injuryen_US
dc.typeArticleen_US

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