Meiotic segregation analysis of reciprocal translocations, both in sperms and blastomeres

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dc.contributor.authorYakut, Tahsin
dc.contributor.authorErçelen, Nesrin
dc.contributor.authorAcar, Hasan
dc.contributor.authorKimya, Yalçın
dc.contributor.authorEgeli, Ünal
dc.date.accessioned2020-03-26T17:03:52Z
dc.date.available2020-03-26T17:03:52Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBalanced chromosomal rearrangements could lead to unbalanced segregation gametes during meiosis. In this Study, sperm flourescence ill situ hybridization (FISH) analysis of meiotic segregation products of four reciprocal translocations; 46,XY,t(7;10)(q21;q22), 46:XY,t(15;17)(q11;p12), 46,XY, t(6;13)(p21.1;q32), and 46,XY,t(1;13)(q24;q10) are presented. In three Out Of these four cases with t(15;17), t(6;13), and t(1;13) additional blastomere FISH analyses are also provided. multi-color FISH analysis was applied using diverse probe combinations specific for translocated chromosome segments. The average frequency of sperm nuclei bearing unbalanced products for t(7;10), t(15:17), t(6;13), and t(1;13) were 48.7%, 59.5%, 60.5%, and 62.9%, respectively. Frequencies of blastomeres comprising unbalanced products in Cases with t(15;17), t(6;13), and t(1:13) were 80% (12 of 15), 60% (3 of 5), and 50% (2 of 4), respectively. Chi-square test analysis showed significant differences in the meiotic segregation pattens Clue to the distribution and numbers of the chiasmatas that Could depend oil the size of the translocated segments (P < 0.001). In conclusion, FISH analysis of sperm and blastomere for reciprocal translocation carriers effectively estimates the approximate risk Of unbalanced products and this result might ensure Valuable genetic Counseling. (c) 2006 Wiley-Liss, Inc.en_US
dc.identifier.doi10.1002/ajmg.a.31215en_US
dc.identifier.endpage1082en_US
dc.identifier.issn1552-4825en_US
dc.identifier.issue10en_US
dc.identifier.pmid16596678en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1074en_US
dc.identifier.urihttps://dx.doi.org/10.1002/ajmg.a.31215
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20577
dc.identifier.volume140Aen_US
dc.identifier.wosWOS:000237171100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-LISSen_US
dc.relation.ispartofAMERICAN JOURNAL OF MEDICAL GENETICS PART Aen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectReciprocal translocationen_US
dc.subjectMeiotic segregationen_US
dc.subjectSpermen_US
dc.subjectBlastomereen_US
dc.titleMeiotic segregation analysis of reciprocal translocations, both in sperms and blastomeresen_US
dc.typeArticleen_US

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