D-dimer and D-dimer/fibrinogen ratio in predicting pulmonary embolism in patients evaluated in a hospital emergency department

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dc.contributor.authorKara, Hasan
dc.contributor.authorBayır, Ayşegül
dc.contributor.authorDeğirmenci, Selim
dc.contributor.authorKayış, Seyit Ali
dc.contributor.authorAkıncı, Murat
dc.contributor.authorAk, Ahmet
dc.contributor.authorÇelik, Bülent
dc.contributor.authorDoğru, Ali
dc.contributor.authorÖztürk, B.
dc.date.accessioned2020-03-26T18:49:57Z
dc.date.available2020-03-26T18:49:57Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: The D-dimer level, fibrinogen level, and D-dimer/fibrinogen ratio are used in the diagnosis of pulmonary embolism, but results vary. We evaluated these parameters in the diagnosis of pulmonary embolism in emergency clinic patients. Methods: In this prospective study, 200 patients (pulmonary embolism, 100 patients; no pulmonary embolism, 100 patients) had D-dimer and fibrinogen levels measured before intervention. Pulmonary embolism was diagnosed with computed tomography angiography or ventilation-perfusion scintigraphy. Results: Compared with patients who did not have pulmonary embolism, patients who had pulmonary embolism had significantly greater mean D-dimer level (pulmonary embolism, 6 +/- 7 mu g/ml; no pulmonary embolism, 1 +/- 1 mu g/ml; P <= 0.001) and D-dimer/fibrinogen ratio (pulmonary embolism, 3 +/- 3; no pulmonary embolism, 0.4 +/- 0.4; P <= 0.001), but similar mean fibrinogen levels (pulmonary embolism, 337 +/- 184 mg/dl; no pulmonary embolism, 384 +/- 200 mg/dl; not significant). In patients who had pulmonary embolism, mean D-dimer level and D-dimer/fibrinogen ratio were greater in high-risk than non-high-risk patients. With D-dimer cutoff 0.35 mu g/ml, sensitivity was high (100%) and specificity was low (27%) for pulmonary embolism. With D-dimer/fibrinogen ratio cutoff 0.13, sensitivity was high (100%) and specificity was low (37%) for pulmonary embolism. Conclusion: A D-dimer level <0.35 mu g/ml may exclude the diagnosis of pulmonary embolism. At a D-dimer cutoff 0.5 mu g/ml and D-dimer/fibrinogen ratio cutoff 1.0, the D-dimer/fibrinogen ratio may have better specificity than D-dimer level in the diagnosis of pulmonary embolism, but the D-dimer/fibrinogen ratio may lack sufficient specificity in screening.en_US
dc.identifier.doi10.1179/2295333714Y.0000000029en_US
dc.identifier.endpage245en_US
dc.identifier.issn1784-3286en_US
dc.identifier.issn2295-3337en_US
dc.identifier.issue4en_US
dc.identifier.pmid25012747en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage240en_US
dc.identifier.urihttps://dx.doi.org/10.1179/2295333714Y.0000000029
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30718
dc.identifier.volume69en_US
dc.identifier.wosWOS:000339727900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMANEY PUBLISHINGen_US
dc.relation.ispartofACTA CLINICA BELGICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectThromboembolic diseaseen_US
dc.subjectDiagnosisen_US
dc.subjectUrgent careen_US
dc.subjectFibrin degradation productsen_US
dc.titleD-dimer and D-dimer/fibrinogen ratio in predicting pulmonary embolism in patients evaluated in a hospital emergency departmenten_US
dc.typeArticleen_US

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