Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'Similarities and differences'

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dc.contributor.authorKeles, Sevgi
dc.contributor.authorArtac, Hasibe
dc.contributor.authorKara, Reyhan
dc.contributor.authorGokturk, Bahar
dc.contributor.authorOzen, Ahmet
dc.contributor.authorReisli, Ismail
dc.date.accessioned2020-03-26T18:05:29Z
dc.date.available2020-03-26T18:05:29Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTransient hypogammaglobulinemia of infancy (THI) is characterized by recurrent infections and one or more reduced serum immunoglobulin (Ig) levels. Usually, this clinical picture resolves spontaneously by 3 yr of age. However, hypogammaglobulinemia persists until adolescence in some patients. In recent years, those patients have been classified as undefined/unclassified hypogammaglobulinemia (UCH). We aimed to evaluate the clinical and immunologic features of patients with THI and UCH considering age of recovery and to assess relationships between hypogammaglobulinemia, infections, and allergic manifestations. We reviewed the medical records of children followed with a diagnosis of hypogammaglobulinemia from 2001 to 2007. Patients with decreased levels (< 2 s.d.) of one or more major Ig isotypes (IgG, IgA, IgM) with normal antibody responses and lymphocyte subpopulations were included (n = 374). Those patients whose Igs normalized during the follow-up period were classified as THI and the others as UCH. The THI group consisted of 71 patients (27 females, 44 males) with a mean recovery age of 68.87 +/- 36.5 months. About 95% of patients with THI recovered before 10 yr of age. The UCH group consisted of 303 patients (105 females, 198 males) with a mean age at diagnosis of 52 +/- 42 months. The most common presenting manifestations in the THI and UCH groups were upper respiratory tract infections (URTIs), lower respiratory tract infections, and asthma (42%, 50%, and 52% in the THI group vs. 39%, 53%, and 55% in the UCH group, respectively). In the THI group, the prevalence of atopic disease was related to age and found to be increased markedly after 44 months. In all patients, the prevalence of asthma was independently and positively associated with family history of atopy and age, whereas it was negatively associated with recurrent URTIs. Patients with THI and UCH have similar clinical and immunologic features. The normalization of Igs may be delayed in a majority of the patients with hypogammaglobulinemia. This observation may be a contribution to the classical definition and diagnostic criteria for THI.en_US
dc.identifier.doi10.1111/j.1399-3038.2010.01010.xen_US
dc.identifier.endpage851en_US
dc.identifier.issn0905-6157en_US
dc.identifier.issn1399-3038en_US
dc.identifier.issue5en_US
dc.identifier.pmid20609138en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage843en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1399-3038.2010.01010.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25441
dc.identifier.volume21en_US
dc.identifier.wosWOS:000280200000007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofPEDIATRIC ALLERGY AND IMMUNOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectallergyen_US
dc.subjectchildrenen_US
dc.subjectprimary immunodeficiencyen_US
dc.subjecttransient hypogammaglobulinemia of infancyen_US
dc.subjectunclassified hypogammaglobulinemiaen_US
dc.titleTransient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'Similarities and differences'en_US
dc.typeArticleen_US

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