Brain tissue biochemical parameters in cerebral ischemic reperfusion injury after hemorrhagic shock: An experimental study
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
UNIVERSITATSVERLAG ULM GMBH
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: In this study, we showed the tissue biochemical parameters in cerebral ischemic reperfusion injury that developed after hemorrhagic shock in a rat model. Materials and Methods: Hemorrhagic shock models were established in 36 adult Sprague-Dawley rats and divided into six groups: control (group A), hemorrhagic shock (HS) (group B), first hour ischemic reperfusion (IR+1h) (group Q, 311 hour IR (IR+3h) (group D), 61(th) hour IR (IR+6h) (group E) and 2411 hour IR (IR+24h) (group F). The rats were sacrificed by bleeding from the intracardiac area after finishing the experiment. The brains were removed from the skull immediately. Bilateral hemispheres were dissected for biochemical analyses, and activities of superoxide dismutase (SOD) and myeloperoxidase (MPO), and the levels of malondialdehyde (MDA) were evaluated. Results: The study revealed that the SOD activities decreased stepwise from group A (control) to group F (IR+24h) (P<0.05). In addition, MDA levels and MPO activities increased stepwise from group A (control) to group F (IR+24h). Conclusion: We think that the level of cell injury increases stepwise in the first, 3(rd), 6(th) and 24(th) hours after ischemia reperfusion injury.
Açıklama
Anahtar Kelimeler
cerebral injury, hemorrhagic shock, ischemia-reperfusion
Kaynak
NEUROLOGY PSYCHIATRY AND BRAIN RESEARCH
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
14
Sayı
1
