Brain tissue biochemical parameters in cerebral ischemic reperfusion injury after hemorrhagic shock: An experimental study

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dc.contributor.authorCosar, Murat
dc.contributor.authorEser, Olcay
dc.contributor.authorFidan, Hueseyin
dc.contributor.authorKalkan, Erdal
dc.contributor.authorBuyukbas, Sadik
dc.contributor.authorOzen, O. A.
dc.date.accessioned2020-03-26T17:17:04Z
dc.date.available2020-03-26T17:17:04Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: In this study, we showed the tissue biochemical parameters in cerebral ischemic reperfusion injury that developed after hemorrhagic shock in a rat model. Materials and Methods: Hemorrhagic shock models were established in 36 adult Sprague-Dawley rats and divided into six groups: control (group A), hemorrhagic shock (HS) (group B), first hour ischemic reperfusion (IR+1h) (group Q, 311 hour IR (IR+3h) (group D), 61(th) hour IR (IR+6h) (group E) and 2411 hour IR (IR+24h) (group F). The rats were sacrificed by bleeding from the intracardiac area after finishing the experiment. The brains were removed from the skull immediately. Bilateral hemispheres were dissected for biochemical analyses, and activities of superoxide dismutase (SOD) and myeloperoxidase (MPO), and the levels of malondialdehyde (MDA) were evaluated. Results: The study revealed that the SOD activities decreased stepwise from group A (control) to group F (IR+24h) (P<0.05). In addition, MDA levels and MPO activities increased stepwise from group A (control) to group F (IR+24h). Conclusion: We think that the level of cell injury increases stepwise in the first, 3(rd), 6(th) and 24(th) hours after ischemia reperfusion injury.en_US
dc.identifier.endpage24en_US
dc.identifier.issn0941-9500en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21248
dc.identifier.volume14en_US
dc.identifier.wosWOS:000249575600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUNIVERSITATSVERLAG ULM GMBHen_US
dc.relation.ispartofNEUROLOGY PSYCHIATRY AND BRAIN RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcerebral injuryen_US
dc.subjecthemorrhagic shocken_US
dc.subjectischemia-reperfusionen_US
dc.titleBrain tissue biochemical parameters in cerebral ischemic reperfusion injury after hemorrhagic shock: An experimental studyen_US
dc.typeArticleen_US

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