Henoch Schonlein purpura in childhood: clinical analysis of 254 cases over a 3-year period

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dc.contributor.authorPeru, Harun
dc.contributor.authorSoylemezoglu, Oguz
dc.contributor.authorBakkaloglu, Sevcan Azime
dc.contributor.authorElmas, Sefika
dc.contributor.authorBozkaya, Davut
dc.contributor.authorElmaci, Ahmet Midhat
dc.contributor.authorKara, Fatih
dc.date.accessioned2020-03-26T17:27:00Z
dc.date.available2020-03-26T17:27:00Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe aimed to evaluate the patients who were diagnosed as Henoch Schonlein purpura (HSP) for disease characteristics and prognosis of those with joint, gastrointestinal (GI), and renal involvement. Two hundred and fifty-four children who were followed up with the diagnosis of HSP in the Pediatric Nephrology Clinics of Meram Medical Faculty of Selcuk University and Medical Faculty of Gazi University between January 2003 and June 2006 were retrospectively evaluated. The clinical follow-up and treatment regimens of patients in whom renal biopsy was performed were evaluated in detail. The study group consisted of 254 children, 147 boys (57.8%) and 107 girls (42.2%), and the ratio of boys to girls was 1.37. The percentages of skin, joint, GI, and renal manifestations were 100%, 66%, 56%, and 30%, respectively. Eight patients had intussusception. Five of them recovered with steroid treatment only while three patients were operated on. Sixty-four patients (44%) with GI involvement had severe disease and were successfully treated with steroids. Renal biopsy was performed in 26 patients. Among those 26 patients, two of them recovered spontaneously within 3 and 4 weeks. Ten patients improved with only steroid treatment while 12 patients recovered with steroid and cyclophosphamide treatment. Two patients were resistant to steroid and cyclophosphamide treatment and were treated with cyclosporine A. We believe that steroid therapy given to the HSP patients with GI manifestations might be helpful to prevent probable complications such as GI bleeding and intussusception. In addition, combined therapy with steroid and cyclophosphamide can usually be an appropriate treatment for patients with nephrotic proteinuria.en_US
dc.identifier.doi10.1007/s10067-008-0868-2en_US
dc.identifier.endpage1092en_US
dc.identifier.issn0770-3198en_US
dc.identifier.issue9en_US
dc.identifier.pmid18305976en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1087en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10067-008-0868-2
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22439
dc.identifier.volume27en_US
dc.identifier.wosWOS:000257919200003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER LONDON LTDen_US
dc.relation.ispartofCLINICAL RHEUMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectgastrointestinal manifestationsen_US
dc.subjectHenoch Schonlein purpuraen_US
dc.subjectjoint manifestationsen_US
dc.subjectrenal manifestationsen_US
dc.titleHenoch Schonlein purpura in childhood: clinical analysis of 254 cases over a 3-year perioden_US
dc.typeArticleen_US

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