Measurements of caffeine and plasma metabolite/caffeine ratios as a test for hepatic drug-oxidizing capacity in goats

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dc.contributor.authorUney, Kamil
dc.contributor.authorTumer, Ilyas
dc.contributor.authorTras, Bunyamin
dc.date.accessioned2020-03-26T18:15:13Z
dc.date.available2020-03-26T18:15:13Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this investigation was to determine the pharmacokinetics and demethylation of caffeine (CF) and the metabolite/CF ratios that correlated best with CF clearance, which were used to evaluate hepatic drug-oxidizing capacity of CF after a single intravenous dose (5 mg/kg) in hair goats (n == 9). Pharmacokinetic parameters of CF and its metabolites, theobromine (TB), paraxanthine (PX) and theophylline (TP), were calculated. The plasma metabolic ratios TB/CF, PX/CF, TP/CF and TB++PX++TP/CF were determined at 6, 8 and 10 h after CF administration to evaluate their hepatic drug-oxidizing capacity. The plasma concentration--time data of CF were fit to a two-compartment model in all animals. The clearance of CF was 0.08 +/-+/- 0.02 L/h/kg, and the volume of distribution was 0.91 +/-+/- 0.16 L/kg. The demethylation fractions of CF to TB, PX and TP were 0.24, 0.37 and 0.39, respectively. Correlations between the metabolic ratios and CF clearance were quite high, except for the PX/CF ratio, particularly at 6 h (r == 0.650--0.750, P < 0.01, 0.05) and 10 h (r == 0.650--0.767, P < 0.01, 0.05). Plasma metabolite/CF ratios, except for the PX/CF ratio, may be useful as an alternative to measurements of CF clearance for the determination of the hepatic drug-oxidizing capacity in goats.en_US
dc.identifier.doi10.3109/00498254.2011.572199en_US
dc.identifier.endpage592en_US
dc.identifier.issn0049-8254en_US
dc.identifier.issn1366-5928en_US
dc.identifier.issue7en_US
dc.identifier.pmid21476905en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage585en_US
dc.identifier.urihttps://dx.doi.org/10.3109/00498254.2011.572199
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26633
dc.identifier.volume41en_US
dc.identifier.wosWOS:000291537900008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofXENOBIOTICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCaffeine pharmacokineticsen_US
dc.subjectplasma metabolic ratiosen_US
dc.subjecthair goatsen_US
dc.titleMeasurements of caffeine and plasma metabolite/caffeine ratios as a test for hepatic drug-oxidizing capacity in goatsen_US
dc.typeArticleen_US

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