A Comparison of the Hemodynamic and Metabolic Effects of Extraperitoneal Carbon Dioxide and Nitrous Oxide Insufflation

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dc.contributor.authorAksoy, Faruk
dc.contributor.authorBelviranlı, Metin
dc.contributor.authorVatansev, Celalettin
dc.contributor.authorTuncer, Sema
dc.contributor.authorYol, Serdar
dc.contributor.authorÖzergin, Ufuk
dc.contributor.authorAtabek, Mustafa
dc.date.accessioned2020-03-26T16:36:56Z
dc.date.available2020-03-26T16:36:56Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The aim of the present study was to compare the hemodynamic and metabolic effects of extraperitoneal carbon dioxide (CO2)and nitrous oxide. (N2O) insufflation. Material and methods: Fourteen dogs were used in the experiment. All the animals were intubated under general anesthesia. A catheter was placed into the right juguler vein for central venous pressure (CVP), pulmonary artery pressure (PAP), pulmonary wedge pressure (PWP), and heart rate (HR) monitorization. End-tidal CO2 pressure was measured by a capnometer connected to the endotracheal tube. Another catheter was inserted into the left femoral artery for arterial blood gas analysis and blood pressure monitorization. The preperitoneal dissection was made from a 1.5 cm subumbilical incision by using a preperitoneal dissection balloon. A laparoscope was placed in the preperitoneal space and the gas insufflation was kept at a constant pressure of 12 mm Hg throughout the experiment. All the study parameters were measured at the beginning of the insufflation and at every 15 minutes for 1 hour. Results: Mean artery pressure increased with time in both groups, but the increase was only significant in the CO2 group. PWP, CVP, PAP, and HR increased slightly in both groups, but there was no significant difference between the groups. The end-tidal CO2 increased in the CO2 group but decreased from the baseline in the N2O group. A significant acidosis was observed in only the CO2 group. PaCO2 significantly increased in the CO2 group; hence, PaCO2 slightly decreased in N2O group. The difference between the groups was significant. Conclusions: N2O insufflation of the extraperitoneal space in dogs avoided the unwanted metabolic and hemodynamic side effects of CO2 insufflation. Thus, N2O insufflation in the extraperitoneal space is a safer alternative to CO2 insufflation experimentally, and can be preferred especially in patients with cardiac and pulmonary diseases.en_US
dc.identifier.citationAksoy, F., Belviranlı, M., Vatansev, C., Tuncer, S., Yol, S., Özergin, U., Atabek, M., (2001). A Comparison of the Hemodynamic and Metabolic Effects of Extraperitoneal Carbon Dioxide and Nitrous Oxide Insufflation. American Journal of Surgery, 182(5), 486-490. DOI: 10.1016/S0002-9610(01)00743-7
dc.identifier.doi10.1016/S0002-9610(01)00743-7en_US
dc.identifier.endpage490en_US
dc.identifier.issn0002-9610en_US
dc.identifier.issue5en_US
dc.identifier.pmid11754856en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage486en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0002-9610(01)00743-7
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17491
dc.identifier.volume182en_US
dc.identifier.wosWOS:000172999300010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAksoy, F.
dc.institutionauthorBelviranlı, M.
dc.institutionauthorVatansev, C.
dc.institutionauthorTuncer, S.
dc.institutionauthorYol, S.
dc.institutionauthorÖzergin, U.
dc.institutionauthorAtabek, M.
dc.language.isoenen_US
dc.publisherEXCERPTA MEDICA INCen_US
dc.relation.ispartofAmerican Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCarbon Dioxide Insufflationen_US
dc.subjectNitrous Oxide Insufflationen_US
dc.subjectExtraperitoneal Laparoscopic Approachen_US
dc.titleA Comparison of the Hemodynamic and Metabolic Effects of Extraperitoneal Carbon Dioxide and Nitrous Oxide Insufflationen_US
dc.typeArticleen_US

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