Analysis of chromosomes 9 and 11 aneuploidy frequency in pleural effusion of patients with and without malignancy - Interphase FISH technique

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dc.contributor.authorÇora, Tülin
dc.contributor.authorAcar, Hasan
dc.contributor.authorCeran, Sami
dc.contributor.authorBodur, Said
dc.date.accessioned2020-03-26T16:56:33Z
dc.date.available2020-03-26T16:56:33Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractFluids of body cavities result in a series of pathophysiological events associated with non-malignant and malignant conditions that lead to the formation of exudative effusion. Diagnosis of effusion from the patients is frequently troublesome for the cytologist because of the differentiation and biological behavior of different cells type in effusion. In the present study, chromosomal aneuploidy status in effusion cells derived from 32 patients including 14 patients with non-malignant diseases and 18 patients with malignant diseases [including malign mesothelioma (n = 6), adeno carcinoma (n = 10), small cell carcinoma (n = 2)] was analyzed by using fluorescence in situ hybridization (FISH) with centromere specific probes for chromosomes 9 and 11. There was significant difference in the incidence of chromosomal 9 and 11 aneuploidies when compared with controls (P = 0.000). However, aneuploidies of chromosomes 9 and 11 in effusion cells from patients with malignant disease had significantly higher than in effusion cells from patients with non-malignant (P = 0.000), suggesting that chromosomes 9 and 11 are frequently involved in the status of disease. The present study indicates that there is a association between chromosomes aneuploidies and pleural effusion cell status. Chromosome aneuploidies in non-malignant group may be an indicator of premalignancy.en_US
dc.identifier.endpage251en_US
dc.identifier.issn1538-4047en_US
dc.identifier.issn1555-8576en_US
dc.identifier.issue2en_US
dc.identifier.pmid15753650en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage248en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19594
dc.identifier.volume4en_US
dc.identifier.wosWOS:000231359400018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofCANCER BIOLOGY & THERAPYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAneuploidyen_US
dc.subjectChromosome 9en_US
dc.subjectEffusionen_US
dc.subjectInterphase FISHen_US
dc.titleAnalysis of chromosomes 9 and 11 aneuploidy frequency in pleural effusion of patients with and without malignancy - Interphase FISH techniqueen_US
dc.typeArticleen_US

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