Factors associated with major depressive disorder occurring after the onset of obsessive-compulsive disorder

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dc.contributor.authorBeşiroğlu, Lütfullah
dc.contributor.authorUğuz, Fairuk
dc.contributor.authorSağlam, Mürsel
dc.contributor.authorAğargün, Mehmet Yücel
dc.contributor.authorÇilli, Ali Savaş
dc.date.accessioned2020-03-26T17:17:27Z
dc.date.available2020-03-26T17:17:27Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: We aimed to investigate the correlates of major depressive disorder (MDD) occurring after the onset of obsessive-compulsive disorder (OCD). Methods: Forty-three OCD patients who developed MDD after the onset of OCD (OCD-MDD group) and 67 OCD patients without MDD (non-MDD, NMDD group) were compared with regard to sociodemographic characteristics, clinical history, symptom severity, types of obsessions and compulsions, insight degree, comorbid axis I and axis 11 diagnosis and quality-of-life level. Results: The OCD-MDD group scored significantly higher on measures of obsessions, compulsions and depression severity than did the NMDD. Significantly more aggressive obsessions were identified in the OCD-MDD group than in the NMDD group. The OCD-MDD group was also significantly more likely than the NMDD group to have generalized anxiety disorder (GAD), There was no significant difference in the rate of personality disorders between the groups. The OCD-MDD group reported significantly lower levels of quality of life (QOL) in the domains of physical health, psychological health and social relationships. Depression severity was associated with obsession but not with compulsion severity. In a logistic regression model, obsession severity, presence of GAD and aggressive obsessions emerged as the factors associated with the occurrence of MDD. Limitations: To exclude ineligible patients, we gathered the information about past mood episodes cross-sectionally. Conclusions: These results suggest that psychopathological processes mediated by specific obsessions as well as excessive anxiety and worries may render the neurocircuities more vulnerable to the development of MDD. The occurrence of MDD in OCD cannot sufficiently be explained as a secondary complication to the disability of OCD. (c) 2006 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jad.2006.12.007en_US
dc.identifier.endpage79en_US
dc.identifier.issn0165-0327en_US
dc.identifier.issn1573-2517en_US
dc.identifier.issue01.03.2020en_US
dc.identifier.pmid17222458en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jad.2006.12.007
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21402
dc.identifier.volume102en_US
dc.identifier.wosWOS:000248823300009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofJOURNAL OF AFFECTIVE DISORDERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectobsessive-compulsive disorderen_US
dc.subjectdepressionen_US
dc.subjectobsessionen_US
dc.subjectComorbidityen_US
dc.subjectgeneralized anxiety disorderen_US
dc.subjectquality of lifeen_US
dc.titleFactors associated with major depressive disorder occurring after the onset of obsessive-compulsive disorderen_US
dc.typeArticleen_US

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