Effect of pinealectomy on homocysteine levels in ovariectomized rats

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dc.contributor.authorOztekin, Esma
dc.contributor.authorOzturk, Bahadir
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorTiftik, Ali Muhtar
dc.date.accessioned2020-03-26T17:17:18Z
dc.date.available2020-03-26T17:17:18Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVE: Hyperhomocysteinemia plays a role in obstetric and gynecological diseases and such diseases are seen as a consequence of an impaired methionine cycle. In the present study, it was aimed to determine the effect of estradiol and progesterone on homocysteine levels in pinealectomized and ovariectomized rats. MATERIALS AND METHODS: The study was carried out on 24 adult Spraque-Dawley female rats. Rats were divided into 4 groups as follows: Group 1: Sham ovariectomy group (Sham-Ovx), Group 2: Ovariectomized and sham pinealectomized group (Ovx-Sham-Px), Group 3: Ovariectomized and pinealectomized group (Ovx-Px), Group 4: Group which were supplemented with estradiol and progesterone after ovariectomy and pinealectomy (Ovx-Px-E+P). Serum homocysteine levels were determined after experimental period. RESULTS: Homocysteine levels in Group 3 were higher than those in Groups 1, 2 and 4 (p<0.05). Homocysteine levels in Groups 2 and 4 were higher than those in Group 1 (p<0.05). Homocysteine levels in Groups 2 and 4 were not different. CONCLUSION: The findings of the present study demonstrate that ovariectomy lead to increases homocysteine levels. Pinealectomy in addition to ovariectomy increases homocysteine levels. However, administration of estradiol and progesterone following pinealectomy prevents the increase in homocysteine levels in ovariectomized rats.en_US
dc.identifier.endpage720en_US
dc.identifier.issn0172-780Xen_US
dc.identifier.issue5en_US
dc.identifier.pmid17984942en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage717en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21349
dc.identifier.volume28en_US
dc.identifier.wosWOS:000251986200040en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMAGHIRA & MAAS PUBLICATIONSen_US
dc.relation.ispartofNEUROENDOCRINOLOGY LETTERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectovariectomyen_US
dc.subjectpinealectomyen_US
dc.subjecthomocysteineen_US
dc.subjectestradiolen_US
dc.subjectprogesteroneen_US
dc.subjectraten_US
dc.titleEffect of pinealectomy on homocysteine levels in ovariectomized ratsen_US
dc.typeArticleen_US

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