Comparison of the effects of aromatase inhibitors and tamoxifen on radiation-induced lung toxicity: results of an experimental study

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dc.contributor.authorYavas, Guler
dc.contributor.authorYavas, Cagdas
dc.contributor.authorAcar, Hilal
dc.contributor.authorToy, Hatice
dc.contributor.authorYuce, Deniz
dc.contributor.authorAta, Ozlem
dc.date.accessioned2020-03-26T18:41:20Z
dc.date.available2020-03-26T18:41:20Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe purpose of this study is to compare the effects of anastrozole, letrozole and tamoxifen on radiation-induced pulmonary fibrosis. Eighty female Wistar albino rats were divided into eight groups. Group (G) 1 was defined as control group. G2 was radiation therapy (RT) only group. Groups 3, 4 and 5 were tamoxifen, anastrozole and letrozole control groups respectively. Groups 6, 7 and 8 were RT plus tamoxifen, anastrozole and letrozole groups, respectively. A single dose of 12 Gy RT was given to both lungs. Tamoxifen, anastrozole and letrozole were started 1 week before the RT and continued until the animals were sacrificed 16 weeks after the RT. As an end point, the extent of pulmonary fibrosis for each rat was quantified with image analysis of histological sections of the lung. Kruskal-Wallis and Mann-Whitney U tests were used for statistical analyses. The congestion, inflammation and pulmonary fibrosis scores were significantly different between all the study groups (p values were < 0.001 for each). When compared with RT only group, concomitant RT and tamoxifen group increased the radiation-induced pulmonary fibrosis (p = 0.005). However, using either anastrozole or letrozole with RT did not increase the radiation-induced pulmonary fibrosis (p values were 0.768 and 0.752, respectively). Concomitant use of tamoxifen with RT seems to increase radiation-induced pulmonary toxicity. However, the use of both anastrozole and letrozole appears to be safe with concomitant RT, without increasing the risk of pulmonary fibrosis. This finding should be clarified with further clinical studies.en_US
dc.description.sponsorshipSelcuk University, Selcuklu Faculty of MedicineSelcuk University [SUSFM 12401036]en_US
dc.description.sponsorshipThis work is supported by Selcuk University, Selcuklu Faculty of Medicine (SUSFM 12401036). There is no role of study sponsors in the study design, in the collection, analysis and interpretation of data; in the writing of the manuscript and in the decision to submit the manuscript for publication.en_US
dc.identifier.doi10.1007/s00520-012-1584-7en_US
dc.identifier.endpage817en_US
dc.identifier.issn0941-4355en_US
dc.identifier.issn1433-7339en_US
dc.identifier.issue3en_US
dc.identifier.pmid22941118en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage811en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00520-012-1584-7
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29320
dc.identifier.volume21en_US
dc.identifier.wosWOS:000314301900017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofSUPPORTIVE CARE IN CANCERen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnastrozoleen_US
dc.subjectLetrozoleen_US
dc.subjectPulmonary toxicityen_US
dc.subjectRadiotherapyen_US
dc.subjectTamoxifenen_US
dc.titleComparison of the effects of aromatase inhibitors and tamoxifen on radiation-induced lung toxicity: results of an experimental studyen_US
dc.typeArticleen_US

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