Cross-Over, Open-Label Trial of the Effects of Gabapentin versus Pregabalin on Painful Peripheral Neuropathy and Health-Related Quality of Life in Haemodialysis Patients

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dc.contributor.authorAtalay, Huseyin
dc.contributor.authorSolak, Yalcin
dc.contributor.authorBiyik, Zeynep
dc.contributor.authorGaipov, Abduzhappar
dc.contributor.authorGuney, Figen
dc.contributor.authorTurk, Suleyman
dc.date.accessioned2020-03-26T18:41:24Z
dc.date.available2020-03-26T18:41:24Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPainful peripheral neuropathy (PPN) is common in haemodialysis patients and associated with impaired health-related quality of life (HR-QoL). Gabapentin and pregabalin have not been fully investigated in haemodialysis patients. Therefore, we compared the effects of gabapentin and pregabalin on intensity of pain and associated HR-QoL in haemodialysis patients with PPN. Gabapentin and pregabalin were administered after each haemodialysis session at doses of 300 and 75 mg, respectively. Patients were randomized into two groups; after 6 weeks patients underwent a 2-week washout and crossover and received another 6 weeks of treatment. All patients underwent electromyography at the outset. The short-form McGill pain questionnaire (SF-MPQ) for assessment of pain, and short-form medical outcomes study for assessment of HR-QoL at baseline and at the end of the study were applied. Forty patients completed the 14-week study period. Gabapentin and pregabalin significantly improved SF-MPQ total scores compared with pretreatment values (mean +/- A SD) [from 18.9 +/- A 4.3 to 9.3 +/- A 4.3 for gabapentin, p < 0.001, and from 18.5 +/- A 3.9 to 9.8 +/- A 3.6 for pregabalin, p < 0.001]. There was no significant difference between the study drugs in terms of efficacy against neuropathic pain (p > 0.05). Both gabapentin and pregabalin significantly improved HR-QoL at the end of the study compared with pretreatment scores (p < 0.001). Our results showed strong efficacy of gabapentin and pregabalin on pain intensity in the given doses. HR-QoL was also significantly improved by both drugs.en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects Coordinating OfficeSelcuk University [08102027]; ERA-EDTA fellowship programmeen_US
dc.description.sponsorshipThis project was supported by Selcuk University Scientific Research Projects Coordinating Office (Project Number: 08102027). Dr. A. Gaipov received grant support from the ERA-EDTA fellowship programme.en_US
dc.identifier.doi10.1007/s40261-013-0080-2en_US
dc.identifier.endpage408en_US
dc.identifier.issn1173-2563en_US
dc.identifier.issn1179-1918en_US
dc.identifier.issue6en_US
dc.identifier.pmid23572323en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage401en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s40261-013-0080-2
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29341
dc.identifier.volume33en_US
dc.identifier.wosWOS:000319478500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherADIS INT LTDen_US
dc.relation.ispartofCLINICAL DRUG INVESTIGATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleCross-Over, Open-Label Trial of the Effects of Gabapentin versus Pregabalin on Painful Peripheral Neuropathy and Health-Related Quality of Life in Haemodialysis Patientsen_US
dc.typeArticleen_US

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