Cross-Over, Open-Label Trial of the Effects of Gabapentin versus Pregabalin on Painful Peripheral Neuropathy and Health-Related Quality of Life in Haemodialysis Patients
dc.contributor.author | Atalay, Huseyin | |
dc.contributor.author | Solak, Yalcin | |
dc.contributor.author | Biyik, Zeynep | |
dc.contributor.author | Gaipov, Abduzhappar | |
dc.contributor.author | Guney, Figen | |
dc.contributor.author | Turk, Suleyman | |
dc.date.accessioned | 2020-03-26T18:41:24Z | |
dc.date.available | 2020-03-26T18:41:24Z | |
dc.date.issued | 2013 | |
dc.department | Selçuk Üniversitesi | en_US |
dc.description.abstract | Painful peripheral neuropathy (PPN) is common in haemodialysis patients and associated with impaired health-related quality of life (HR-QoL). Gabapentin and pregabalin have not been fully investigated in haemodialysis patients. Therefore, we compared the effects of gabapentin and pregabalin on intensity of pain and associated HR-QoL in haemodialysis patients with PPN. Gabapentin and pregabalin were administered after each haemodialysis session at doses of 300 and 75 mg, respectively. Patients were randomized into two groups; after 6 weeks patients underwent a 2-week washout and crossover and received another 6 weeks of treatment. All patients underwent electromyography at the outset. The short-form McGill pain questionnaire (SF-MPQ) for assessment of pain, and short-form medical outcomes study for assessment of HR-QoL at baseline and at the end of the study were applied. Forty patients completed the 14-week study period. Gabapentin and pregabalin significantly improved SF-MPQ total scores compared with pretreatment values (mean +/- A SD) [from 18.9 +/- A 4.3 to 9.3 +/- A 4.3 for gabapentin, p < 0.001, and from 18.5 +/- A 3.9 to 9.8 +/- A 3.6 for pregabalin, p < 0.001]. There was no significant difference between the study drugs in terms of efficacy against neuropathic pain (p > 0.05). Both gabapentin and pregabalin significantly improved HR-QoL at the end of the study compared with pretreatment scores (p < 0.001). Our results showed strong efficacy of gabapentin and pregabalin on pain intensity in the given doses. HR-QoL was also significantly improved by both drugs. | en_US |
dc.description.sponsorship | Selcuk University Scientific Research Projects Coordinating OfficeSelcuk University [08102027]; ERA-EDTA fellowship programme | en_US |
dc.description.sponsorship | This project was supported by Selcuk University Scientific Research Projects Coordinating Office (Project Number: 08102027). Dr. A. Gaipov received grant support from the ERA-EDTA fellowship programme. | en_US |
dc.identifier.doi | 10.1007/s40261-013-0080-2 | en_US |
dc.identifier.endpage | 408 | en_US |
dc.identifier.issn | 1173-2563 | en_US |
dc.identifier.issn | 1179-1918 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.pmid | 23572323 | en_US |
dc.identifier.scopusquality | Q2 | en_US |
dc.identifier.startpage | 401 | en_US |
dc.identifier.uri | https://dx.doi.org/10.1007/s40261-013-0080-2 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12395/29341 | |
dc.identifier.volume | 33 | en_US |
dc.identifier.wos | WOS:000319478500002 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | ADIS INT LTD | en_US |
dc.relation.ispartof | CLINICAL DRUG INVESTIGATION | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.selcuk | 20240510_oaig | en_US |
dc.title | Cross-Over, Open-Label Trial of the Effects of Gabapentin versus Pregabalin on Painful Peripheral Neuropathy and Health-Related Quality of Life in Haemodialysis Patients | en_US |
dc.type | Article | en_US |