Comparison of pregnancy outcomes of progesterone or progesterone plus estradiol for luteal phase support in ICSI-ET cycles

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dc.contributor.authorGörkemli, Hüseyin
dc.contributor.authorAk, Dilek
dc.contributor.authorAkyürek, Cemalettin
dc.contributor.authorAktan, Murad
dc.contributor.authorDuman, Selçuk
dc.date.accessioned2020-03-26T16:48:02Z
dc.date.available2020-03-26T16:48:02Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To find out the effect of estradiol with progesterone for luteal phase support in IVF-ICSI cycles. Materials and Methods: Patients were accepted for treatment in the ART unit of Selcuk University, Meram Faculty of Medicine, between January 2001 and March 2003. The study was done in a prospective manner. The age range of 252 women was 19 - 41 years and the total number of cycles was 310. All patients were treated with a long ovulation induction protocol. Patients were treated and divided into two groups in a randomized manner: group I used only 600 mg/day divided into three equal doses of micronized progesterone vaginally, and group II used transdermal estradiol 100 mug/day + 600 mg/day vaginal micronized progesterone. Results: 310 ICSI cycles were carried out in 252 infertile couples between January 2001 and March 2003. From 22 of these cycles, oocytes were retrieved but no embryos were developed. In the remaining 288 cycles there were embryo transfers. All embryo development was achieved by ICSI treatment. In 148 out of 288 cycles, the luteal phase was supported only by vaginal micronized progesterone ( group I). On the other hand, the remaining 140 cycles received vaginal micronized progesterone plus transdermal estradiol 100 mug/day ( group II). The number of beta-hCG-positive results in group I and group II were 20 (13.5 %) and 54 (38.5%) respectively. Conclusion: Adding estradiol to progesterone for luteal phase support in ICSI-ET cycles may increase implantation and pregnancy rates. Copyright (C) 2004 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000079115en_US
dc.identifier.endpage144en_US
dc.identifier.issn0378-7346en_US
dc.identifier.issue3en_US
dc.identifier.pmid15205566en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage140en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000079115
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18975
dc.identifier.volume58en_US
dc.identifier.wosWOS:000224405800005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofGYNECOLOGIC AND OBSTETRIC INVESTIGATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIVF/ICSI cyclesen_US
dc.subjectluteal phase supporten_US
dc.subjectprogesteroneen_US
dc.subjecttransdermal estradiolen_US
dc.titleComparison of pregnancy outcomes of progesterone or progesterone plus estradiol for luteal phase support in ICSI-ET cyclesen_US
dc.typeArticleen_US

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