Effects of sildenafil and vardenafil treatments on sleep quality and depression in hemodialysis patients with erectile dysfunction

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dc.contributor.authorSolak, Y.
dc.contributor.authorAtalay, H.
dc.contributor.authorKan, S.
dc.contributor.authorKaynar, M.
dc.contributor.authorBodur, S.
dc.contributor.authorYeksan, M.
dc.contributor.authorTurk, S.
dc.date.accessioned2020-03-26T18:14:25Z
dc.date.available2020-03-26T18:14:25Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractED is prevalent in hemodialysis (HD) patients, and closely related to poor sleep and depression. Efficacy of treating ED either with sildenafil or vardenafil has been shown to be beneficial in ameliorating concomitant depression in non-HD patients. It is yet to be shown whether treatment of ED with a PDE-5 inhibitor would improve poor sleep in HD patients. We aimed to compare the effects of sildenafil and vardenafil on sleep quality and depression in HD patients with ED. A total of 32 maintenance HD patients with ED randomized into two groups to receive either sildenafil or vardenafil for 4 weeks. After a 2-week washout and a crossover, each group received the other drug for another 4-week period. Sleep quality and depression were evaluated via post-sleep inventory (PSI) and Beck's depression inventory (BDI), respectively, at baseline and at the end of the treatment. Sildenafil and vardenafil both improved PSI and BDI scores significantly compared with pretreatment values. However, there was no difference between sildenafil and vardenafil with respect to these parameters. PDE-5 inhibitors, sildenafil and vardenafil, caused a significant improvement in sleep quality and depression in this cohort of HD patients with ED. International Journal of Impotence Research (2011) 23, 27-31; doi:10.1038/ijir.2010.32; published online 6 January 2011en_US
dc.identifier.doi10.1038/ijir.2010.32en_US
dc.identifier.endpage31en_US
dc.identifier.issn0955-9930en_US
dc.identifier.issue1en_US
dc.identifier.pmid21209618en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://dx.doi.org/10.1038/ijir.2010.32
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26419
dc.identifier.volume23en_US
dc.identifier.wosWOS:000287440300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF IMPOTENCE RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdepressionen_US
dc.subjecterectile dysfunctionen_US
dc.subjectsleep qualityen_US
dc.subjectsildenafilen_US
dc.subjectvardenafilen_US
dc.titleEffects of sildenafil and vardenafil treatments on sleep quality and depression in hemodialysis patients with erectile dysfunctionen_US
dc.typeArticleen_US

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