Effect of melatonin and zinc on the immune response in experimental toxoplasma retinochoroiditis

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dc.contributor.authorAvunduk, Avni Murat
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorBaltacı, Abdülkerim Kasım
dc.contributor.authorMoğulkoç, Rasim
dc.date.accessioned2020-03-26T17:17:18Z
dc.date.available2020-03-26T17:17:18Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: To investigate the possible effect of melatonin (MEL) and zinc on the immune response to Toxoplasma gondii retinochoroiditis in the rat model of infection and to establish the possible value of artificial MEL and/or zinc supplementation as adjunctive therapeutic agents in the treatment of T. gondii retinochoroiditis. Methods: Eighty-four Sprague-Dawley male rats were divided into 12 equal groups. All groups, except controls were infected with T. gondii parasite by intraperitoneal injection. Combinations of zinc-deficient diet, pinealectomy (Px), and artificial zinc and MEL were supplied during a 1-month period. At the end of the experiment, retinal and choroidal total lymphocytes, CD3+, CD4+, and CD8+ cell numbers were counted in histological sections. Results: The highest amount of cellular infiltration (lymphocytes, CD3+, CD4+, CD8+ cells) in the choroid and retina was detected in infected + MEL + zinc-treated rats, and the least amount of cellular infiltration was observed in Px + zinc-deficient diet-treated rats. Although single zinc or MEL supplementation had no significant impact on the cellular infiltration in the retina and choroid in Px rats, combined therapy significantly improved these responses. Conclusion: Artificial supplementation of MEL and zinc should be considered as an adjunctive therapy to classic treatment of Toxoplasma retinochoroiditis especially in immunosuppressed and elderly patients if our data are confirmed in a clinical setting.en_US
dc.identifier.doi10.1159/000107504en_US
dc.identifier.endpage425en_US
dc.identifier.issn0030-3755en_US
dc.identifier.issue6en_US
dc.identifier.pmid17947831en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage421en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000107504
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21346
dc.identifier.volume221en_US
dc.identifier.wosWOS:000250309500010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofOPHTHALMOLOGICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecttoxoplasma gondii retinochoroiditisen_US
dc.subjectzincen_US
dc.subjectmelatoninen_US
dc.subjectpinealectomyen_US
dc.titleEffect of melatonin and zinc on the immune response in experimental toxoplasma retinochoroiditisen_US
dc.typeArticleen_US

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