Epidemiologic survey: reference ranges of serum insulin-like growth factor 1 levels in Caucasian adult population with immunoradiometric assay

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dc.contributor.authorBayram, Fahri
dc.contributor.authorGedik, Vedia Tonyukuk
dc.contributor.authorDemir, Ozgur
dc.contributor.authorKaya, Ahmet
dc.contributor.authorGundogan, Kursat
dc.contributor.authorEmral, Rifat
dc.contributor.authorOzturk, Ahmet
dc.date.accessioned2020-03-26T18:14:30Z
dc.date.available2020-03-26T18:14:30Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractGender, age adjusted, population based reference ranges are necessary to use insulin-like growth factor 1 (IGF-1) as a diagnostic marker or for therapeutic monitoring in growth hormone (GH) related diseases. The aim of the present study was to describe the serum IGF-1 distribution and to calculate age and gender specific reference values for Caucasian adult population. A representative sample of 1002 male and 1039 female, totally 2041 participants aged above 18 years old was examined. The subjects suffering from diabetes mellitus, renal diseases, liver diseases, cancer, or diseases of pituitary gland were excluded by medical history, physical examination, and laboratory tests. The subjects were not using any drug that could affect IGF-1 levels. Body mass index (BMI) >30 or <18 kg/m(2) were excluded. Serum IGF-1 concentrations were determined by immunoradiometric assay (IRMA). Serum IGF-1 concentrations were declined with age in both males and females after the age of 18. Males had significantly higher serum IGF-1 levels than females in the age groups 18-24, 50-69 (P < 0.05), but not in others (P > 0.05). The present study established age and gender specific reference ranges for serum IGF-1 levels calculated for Caucasian adult population with IRMA that could be used in medical practice.en_US
dc.description.sponsorshipSociety of Endocrinology and Metabolism of Turkey (SEMT); Novartis Oncology, Turkeyen_US
dc.description.sponsorshipThis study has been designed, directed, and supported by the Society of Endocrinology and Metabolism of Turkey (SEMT). We thank Ankara University Medical School Endocrinology Laboratory, Erciyes University Medical School Laboratory. Novartis Oncology, Turkey, for providing partial grant support for the determination of plasma samples.en_US
dc.identifier.doi10.1007/s12020-011-9476-zen_US
dc.identifier.endpage309en_US
dc.identifier.issn1355-008Xen_US
dc.identifier.issn1559-0100en_US
dc.identifier.issue2en_US
dc.identifier.pmid21538205en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage304en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s12020-011-9476-z
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26447
dc.identifier.volume40en_US
dc.identifier.wosWOS:000296787800022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofENDOCRINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectInsulin-like growth factor 1en_US
dc.subjectGrowth hormoneen_US
dc.subjectImmunoradiometric assayen_US
dc.titleEpidemiologic survey: reference ranges of serum insulin-like growth factor 1 levels in Caucasian adult population with immunoradiometric assayen_US
dc.typeArticleen_US

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