The effects of zinc deficiency and supplementation on lipid peroxidation in bone tissue of ovariectomized rats

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dc.contributor.authorBaltaci, AK
dc.contributor.authorSunar, F
dc.contributor.authorMogulkoc, R
dc.contributor.authorOztekin, E
dc.date.accessioned2020-03-26T16:55:33Z
dc.date.available2020-03-26T16:55:33Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study aims at investigating how zinc deficiency and zinc application affect lipid peroxidation in bone tissue of ovariectomized rats. The study included 40 adult female rats of Sprague-Dawley species. Group 1 (n = 10): control group were fed with normal diet. Group 2 (n = 10): the group fed with normal diet after being ovariectomized. Group 3 (n = 10): the group fed with zinc-deficient diet for 6 weeks after ovariectomy. Group 4 (n = 10): the group which was given intraperitoneal zinc (3 mg/kg day zinc) in addition to normal diet for 6 weeks after ovariectomy. Malondialdehyde (MDA) and glutathione (GSH) levels were determined in erythrocyte, plasma and bone tissue. Group 3 had the highest plasma MDA levels compared to Groups 1, 2 and 4 (P < 0.05). These values were higher in Group 2 than in Groups 1 and 4 (P < 0.05). Bone and plasma MDA levels in Groups I and 4 were not different. Bone and erythrocyte GSH levels in Group 4 were higher than those in all other groups (P < 0.05). The lowest levels of bone and erythrocyte GSH levels were observed in Group 3 (P < 0.05). These values were higher in Group 2 when compared to those in Groups I and 3 (P < 0.05). This study demonstrate that zinc deficiency increased bone tissue damage in ovariectomized rats and that zinc supplementation prevented this damage. (C) 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.tox.2004.05.021en_US
dc.identifier.endpage82en_US
dc.identifier.issn0300-483Xen_US
dc.identifier.issue01.03.2020en_US
dc.identifier.pmid15363584en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.tox.2004.05.021
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19239
dc.identifier.volume203en_US
dc.identifier.wosWOS:000224332700008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI IRELAND LTDen_US
dc.relation.ispartofTOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectovariectomyen_US
dc.subjectzinc deficiency and supplementationen_US
dc.subjectMDAen_US
dc.subjectGSHen_US
dc.titleThe effects of zinc deficiency and supplementation on lipid peroxidation in bone tissue of ovariectomized ratsen_US
dc.typeArticleen_US

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