Topical Effects of Nebivolol on Wounds in Diabetic Rats

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dc.contributor.authorGülcan, Erim
dc.contributor.authorKüçük, Ayşegül
dc.contributor.authorÇaycı, Kasım
dc.contributor.authorTosun, Murat
dc.contributor.authorEmre, Habib
dc.contributor.authorKoral, Lokman
dc.contributor.authorAktan, Yasemin
dc.contributor.authorAvşar, Ümit
dc.date.accessioned2020-03-26T18:31:57Z
dc.date.available2020-03-26T18:31:57Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Recently, it has reported that nebivolol might be useful in the treatment of diabetes mellitus foot ulcers. The aim of this study was to examine treatment of the wounds in streptozotocin-induced diabetic rats with topical nebivolol. Methods: Two 15 x 15 mm-sized wounds were created in 56 streptozotocin-induced rats. A total of 56 diabetic wounds were studied in eight groups (n = 7). No treatment was administered to the first and second groups. The third and fourth groups consisted of diabetic rats that were administered 1:1 mixture of lanolin and vaseline for 7 and 14 days, respectively. Five percent nebivolol plus 1:1 mixture of lanolin and vaseline was administered to rats in the fifth and sixth groups for 7 and 14 days, respectively, and 10% nebivolol plus 1:1 mixture of lanolin and vaseline was administered to rats in the seventh and eighth groups for 7 and 14 days, respectively. On days 7 and 14, wound healing was observed, and the percent of wound healing was determined by measuring its size and histopathologic examination. The ratio was calculated by the formula, healing ratio (%) = 100 x (1-wound area/initial wound area). Statistical analysis was performed by ANOVA with Tukey's HSD test and Mann-Whitney U test, using SPSS 15.0 software. Results: On days 7 and 14, rates of wound healing in the fifth, sixth, seventh, and eighth groups were 57.42%, 89.16%, 60.80%, and 91.80%, respectively. Multiple comparison showed that rates of wound healing were significantly higher in rats administered 5% and 10% nebivolol than those in rats administered a mixture of lanolin and vaseline and in the untreated group (P < 0.05). Conclusion: Topical nebivolol therapy may be useful for wound healing in diabetic rats. Further studies are needed to support these data.en_US
dc.identifier.citationGülcan, E., Küçük, A., Çaycı, K., Tosun, M., Emre, H., Koral, L., Aktan, Y., Avşar, Ü., (2012). Topical Effects of Nebivolol on Wounds in Diabetic Rats. European Journal of Pharmaceutical Sciences, 47(2), 451-455. DOI: 10.1016/j.ejps.2012.06.017
dc.identifier.doi10.1016/j.ejps.2012.06.017en_US
dc.identifier.endpage455en_US
dc.identifier.issn0928-0987en_US
dc.identifier.issue2en_US
dc.identifier.pmid22820030en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage451en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejps.2012.06.017
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28580
dc.identifier.volume47en_US
dc.identifier.wosWOS:000309029400019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKoral, Lokman
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofEuropean Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNebivolen_US
dc.subjectDiabetic Woundsen_US
dc.subjectNitric Oxideen_US
dc.titleTopical Effects of Nebivolol on Wounds in Diabetic Ratsen_US
dc.typeArticleen_US

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