Oxidative stress in childhood obesity

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dc.contributor.authorAtabek, ME
dc.contributor.authorVatansev, H
dc.contributor.authorErkul, I
dc.date.accessioned2020-03-26T16:55:24Z
dc.date.available2020-03-26T16:55:24Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To measure products of free radical damage in childhood obesity. Methods: Plasma free radicals were assayed in 24 children with exogenous obesity and 24 non-obese healthy controls. A new colorimetric method was used that measures the generation of peroxy radicals (D-Roms), first products of the reaction between free radicals and oxygen. Results: D-Roms levels were higher in the obese children than in the non-obese group (33.3 +/- 10.1 mg% of H2O2 vs 22.8 +/- 2.8 mg% of H2O2; p < 0.001). Moreover, D-Roms levels were higher in children with hyperlipidemia than in children with normolipidemia (49.6 +/- 3.1 mg% of H2O2 vs 27.8 +/- 3.2 mg% of H2O2; p < 0.001). D-Roms level was positively correlated with waist-hip ratio, serum total cholesterol, serum triglycerides, serum low-density lipoprotein-cholesterol, systolic blood pressure, diastolic blood pressure and fasting blood glucose in obese children. In a multivariate regression model for obese children, the independent correlates for D-Roms level were systolic blood pressure (p < 0.001) and serum total cholesterol (p < 0.001), with the total variance explained being 82%. Conclusion: Our study demonstrates for the first time that there was increased D-Roms levels in ob se children and adolescents and suggests that increased systolic blood pressure associated with hyperlipidemia may independently contribute to increased oxidative stress in childhood obesity.en_US
dc.identifier.endpage1068en_US
dc.identifier.issn0334-018Xen_US
dc.identifier.issue8en_US
dc.identifier.pmid15379416en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1063en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19154
dc.identifier.volume17en_US
dc.identifier.wosWOS:000223528400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFREUND PUBLISHING HOUSE LTDen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISMen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectfree radicalsen_US
dc.subjectchildhood obesityen_US
dc.subjecthyperlipidemiaen_US
dc.subjectoxidative stressen_US
dc.titleOxidative stress in childhood obesityen_US
dc.typeArticleen_US

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