Cytotoxicity evaluation of dentin contacting materials with dentin barrier test device using erbium-doped yttrium, aluminum, and garnet laser-treated dentin

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dc.contributor.authorUlker, H. E.
dc.contributor.authorUlker, M.
dc.contributor.authorBotsali, M. S.
dc.contributor.authorDundar, A.
dc.contributor.authorAcar, H.
dc.date.accessioned2020-03-26T18:49:57Z
dc.date.available2020-03-26T18:49:57Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: The effect of dentin contacting materials on three-dimensional cultures of pulp-derived cells was evaluated in a dentin barrier test device using erbium-doped yttrium, aluminum, and garnet (Er:YAG) laser-treated dentin. Methods: The test materials (iBond (R), G-Bond (TM), and Vitrebond (TM)) were applied on laser-treated or untreated dentin discs. After 24 h of exposure with perfusion of the test chamber, cell survival was evaluated by enzyme activity and related to a nontoxic control material. The mean values of control tissues were set to represent 100% viability. Data were analyzed using Kruskal-Wallis and Mann-Whitney U test. Results: Vitrebond was the most toxic material for both laser-treated and untreated dentin. On untreated dentin, G-bond was cytotoxic to the pulp-derived cells (p < 0.05), and iBond was similar to the negative control group (p > 0.05). However, G-Bond and iBond were not cytotoxic when they were applied to Er: YAG laser-treated dentin (p > 0.05). Conclusion: Er: YAG laser treatment of dentin may protect the pulp cells from toxic substances of dentin contacting restorative materials; however, this effect is material related. Taking into consideration the limitations of this in vitro study, the Er: YAG laser treatment of dentin before restoration might be an option for decreasing the cytotoxic effects of the dental materials. Further research is required for clinical applications.en_US
dc.identifier.doi10.1177/0960327113511476en_US
dc.identifier.endpage955en_US
dc.identifier.issn0960-3271en_US
dc.identifier.issn1477-0903en_US
dc.identifier.issue9en_US
dc.identifier.pmid24275641en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage949en_US
dc.identifier.urihttps://dx.doi.org/10.1177/0960327113511476
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30717
dc.identifier.volume33en_US
dc.identifier.wosWOS:000340236300006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofHUMAN & EXPERIMENTAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCytotoxicityen_US
dc.subjectdentin bondingsen_US
dc.subjectEr-YAG laseren_US
dc.subjectdentin barrieren_US
dc.titleCytotoxicity evaluation of dentin contacting materials with dentin barrier test device using erbium-doped yttrium, aluminum, and garnet laser-treated dentinen_US
dc.typeArticleen_US

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