Effects of Magnesium Sulfate on Tissue Lactate and Malondialdehyde Levels in Experimental Head Trauma

Basit Öğe Kaydı
dc.contributor.authorÜstün, Mehmet Erkan
dc.contributor.authorGürbilek, Mehmet
dc.contributor.authorAk, Ahmet
dc.contributor.authorVatansev, Hüsamettin
dc.contributor.authorDuman, Ateş
dc.date.accessioned2020-03-26T16:37:06Z
dc.date.available2020-03-26T16:37:06Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To determine the effects of magnesium sulfate (MgSO4) on tissue lactate and malondialdehyde (MDA) levels in rabbit brain after experimental head trauma. Design: Prospective, randomized trial. Subjects: Thirty New Zealand rabbits. Interventions: Group 1 (n = 10) was the sham operated group. Group 2 (n = 10) (untreated group) and group 3 (n = 10) received head trauma with the weight drop method. MgSO4 was administered 100 mg/kg (15%) i.v. immediately after the head trauma to group 3. Trauma was applied to one side. The non-contused side was named as "a" and the contused side as "b". Measurements: One hour after trauma, brain cortices were resected and the concentrations of lactate and MDA were determined using the spectrophotometric enzymatic and thiobarbituric acid methods. One-way ANOVA and Tukey's HSD tests were used for the evaluation of the results. P < 0.05 was considered as significant. Pearson's correlation test was used between lactate and MDA levels (P < 0.001). Results: There were significant differences between MDA and lactate levels of group 1 and all other groups; non-contused (a) and contused (b) sides of groups 2 and 3; groups 2b-3a, 2b-3b (P < 0.05). The difference in MDA levels was significant between groups 2a-3b (P < 0.05). Correlation between lactate and MDA was very good in group 1, and excellent in groups 2a, 2b, 3a, and 3b. Conclusions: These results demonstrate that head trauma leads to an increase in brain tissue lactate and MDA levels, and MgSO4 suppresses the rise in contused tissue when given after head trauma.en_US
dc.identifier.citationÜstün, M. E., Gürbilek, M., Ak, A., Vatansev, H., Duman, A., (2001). Effects of Magnesium Sulfate on Tissue Lactate and Malondialdehyde Levels in Experimental Head Trauma. Intensive Care Medicine, 27(1), 264-268. Doi:10.1007/s001340000780
dc.identifier.doi10.1007/s001340000780en_US
dc.identifier.endpage268en_US
dc.identifier.issn0342-4642en_US
dc.identifier.issue1en_US
dc.identifier.pmid11280646en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage264en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s001340000780
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17538
dc.identifier.volume27en_US
dc.identifier.wosWOS:000166897700040en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜstün, Mehmet Erkan
dc.language.isoenen_US
dc.publisherSPRINGER-VERLAGen_US
dc.relation.ispartofIntensive Care Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHead Traumaen_US
dc.subjectLactateen_US
dc.subjectLipid Peroxidationen_US
dc.subjectMagnesium Sulfateen_US
dc.subjectMalondialdehydeen_US
dc.titleEffects of Magnesium Sulfate on Tissue Lactate and Malondialdehyde Levels in Experimental Head Traumaen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
s001340000780.pdf
Boyut:
63.54 KB
Biçim:
Adobe Portable Document Format
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Beyin ve Sinir Cerrahisi/Makale Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu