Efficacy of oral rehydration therapy solutions containing sodium bicarbonate or sodium acetate for treatment of calves with naturally acquired diarrhea, moderate dehydration, and strong ion acidosis

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dc.contributor.authorSen, Ismail
dc.contributor.authorAltunok, Vahdettin
dc.contributor.authorOk, Mahmut
dc.contributor.authorCoskun, Alparslan
dc.contributor.authorConstable, Peter D.
dc.date.accessioned2020-03-26T17:38:31Z
dc.date.available2020-03-26T17:38:31Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective-To determine and compare the effects of 4 oral replacement therapy (ORT) solutions on acid-base balance, abomasal emptying rate, and plasma volume expansion in calves with naturally acquired diarrhea and moderate dehydration. Design-Prospective study. Animals-20 calves. Procedures-20 calves up to 45 days of age were randomly allocated (n = 5/group) to receive 2 L of 1 of 4 treatments via oroesophageal intubation: sodium bicarbonate (150 mmol/L or 300 mmol/L) or sodium acetate (150 mmol/L or 300 mmol/L). The 4 test solutions contained acetaminophen (50 mg/kg [22.7 mg/lb]) and 50 g of glucose monohydrate. Jugular venous blood samples were obtained periodically before and after administration of the ORT solution. Abomasal emptying rate was determined by use of the time to maximal plasma acetaminophen concentration. Results-Plasma bicarbonate concentration increased more rapidly in calves administered bicarbonate-containing ORT solutions, whereas the rate of systemic alkalinization, as assessed via blood pH, did not differ consistently among treatments. The 300 mmol/L ORT solutions were emptied at a significantly slower rate from the abomasum than 150 mmol/L ORT solutions, with no difference in emptying rate between acetate and bicarbonate-containing ORT solutions of similar molality. The 300 mmol/L sodium acetate ORT solution significantly increased plasma volume. Conclusions and Clinical Relevance-Clinically important differences in the resuscitative response to 300 mmol/L or 150 mmol/L ORT solutions of sodium acetate or sodium bicarbonate were not identified. (J Am Vet Med Assoc 2009;234:926-934)en_US
dc.description.sponsorshipScientific and Technical Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipSupported by a grant from The Scientific and Technical Research Council of Turkey.en_US
dc.identifier.doi10.2460/javma.234.7.926en_US
dc.identifier.endpage934en_US
dc.identifier.issn0003-1488en_US
dc.identifier.issue7en_US
dc.identifier.pmid19335244en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage926en_US
dc.identifier.urihttps://dx.doi.org/10.2460/javma.234.7.926
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23503
dc.identifier.volume234en_US
dc.identifier.wosWOS:000264540300030en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAMER VETERINARY MEDICAL ASSOCen_US
dc.relation.ispartofJAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEfficacy of oral rehydration therapy solutions containing sodium bicarbonate or sodium acetate for treatment of calves with naturally acquired diarrhea, moderate dehydration, and strong ion acidosisen_US
dc.typeArticleen_US

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