Effect of Viscum album L. ssp. austriacum (WIESP.) Vollman on metronidazole resistant and sensitive strains of Trichomonas vaginalis

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dc.contributor.authorOzpinar, H.
dc.contributor.authorOzpinar, N.
dc.contributor.authorEruygur, N.
dc.date.accessioned2020-03-26T20:13:44Z
dc.date.available2020-03-26T20:13:44Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractTrichomonas vaginalis (T. vaginalis) is a parasitic protozoan that causes trichomoniasis. Metronidazole is the standard treatment for trichomoniasis; however, metronidazole-resistant strains are implicated in an increasing number of refractory cases. Therefore, the discovery of an antiprotozoal agent that is effective on metronidazole-resistant T. vaginalis will prevent major health problems. In this study, we investigated the antiprotozoal effects of leaf, fruit and body extracts of Viscum album L. ssp. austriacum (VA) on metronidazole-resistant and - sensitive T. vaginalis protozoa. The VA used in our study was collected from 20 different pine trees in September and October. The leaves, fruits and bodies of the VA plants collected were separated and dry extracts were obtained with hexane, chloroform, n-butanol, ethyl acetate and water. The minimum lethal dose (MLD) of the metronidazole-sensitive strain, T. vaginalis ATCC50148 and themetronidazole-resistant strain, T. vaginalis ATCC50143 against metronidazole was tested in comparison with the plant extracts. In addition, GC-MS analysis was performed on the plant extracts that has antiprotozoal effects. Some of the substances identified from GC-MS analysis were purchased commercially and their antiprotozoal effects were further investigated. The VA leaf and fruit ethyl acetate extracts and body butanol extract had the most effect on T. vaginalis. GC-MS qualitative analysis detected 2,4-heptadienal, 3-methylsilane, and 2-methylfuran. Of these substances, only 2-methylfuran was found to be effective on T. vaginalis strains. Our findings suggest that the 2-methylfuran found in Viscum album L. ssp. austriacum extracts may be an alternative chemotherapeutic agent to metronidazole. (C) 2019 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipCumhuriyet University Scientific Research Projects UnitCumhuriyet University [ECZ-33]en_US
dc.description.sponsorshipThis study was funded by the Cumhuriyet University Scientific Research Projects Unit (ECZ-33).en_US
dc.identifier.citationOzpinar, H., Ozpinar, N., Eruygur, N. (2019). Effect of Viscum album L. ssp. austriacum (WİESP.) Vollman on Metronidazole Resistant and Sensitive Strains of Trichomonas vaginalis. South African Journal of Botany, 125, 81-85.
dc.identifier.doi10.1016/j.sajb.2019.07.008en_US
dc.identifier.endpage85en_US
dc.identifier.issn0254-6299en_US
dc.identifier.issn1727-9321en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.sajb.2019.07.008
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37752
dc.identifier.volume125en_US
dc.identifier.wosWOS:000488195200011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorEruygur, N.
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofSOUTH AFRICAN JOURNAL OF BOTANYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectViscum albumen_US
dc.subjectTrichomonas vaginalisen_US
dc.subjectMetronidazoleen_US
dc.titleEffect of Viscum album L. ssp. austriacum (WIESP.) Vollman on metronidazole resistant and sensitive strains of Trichomonas vaginalisen_US
dc.typeArticleen_US

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