Childhood, Adolescents, and Young Adults (<= 25 y) Colorectal Cancer: Study of Anatolian Society of Medical Oncology

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dc.contributor.authorKaplan, Muhammet A.
dc.contributor.authorIsikdogan, Abdurrahman
dc.contributor.authorGumus, Mahmut
dc.contributor.authorArslan, Ulku Y.
dc.contributor.authorGeredeli, Caglayan
dc.contributor.authorOzdemir, Nuriye
dc.contributor.authorKoca, Dogan
dc.date.accessioned2020-03-26T18:41:17Z
dc.date.available2020-03-26T18:41:17Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To evaluate the clinicopathologic characteristics and treatment outcomes of young patients with colorectal cancer (CRC). Methods: Between May 2003 and June 2010, 76 patients were found eligible for this retrospective study. Age, sex, presenting symptoms, patients with acute presentation, family history, presence of polyps, histologic features, localization and stage of the tumor, treatment outcomes, time and site of recurrence, sites of metastasis, and survival outcomes were recorded from the patient files. Results: Seventy-six patients (55.3% male) with a median age of 23 years were evaluated. Patients were evaluated in 2 groups as follows: child-adolescent (0 to 19 y, n=20) and young adult (20 to 25 y, n=56). Sex and symptoms (abdominal pain and rectal bleeding) were significantly differed between the groups and acute presentation was close to statistical significance. Overall survival significantly increased in patients undergoing curative surgery (P<0.001). Other parameters affecting the survival was stage of disease (P=0.004). Response to palliative chemotherapy in metastatic patients (P=0.042) and postoperative adjuvant chemotherapy had a statistically significant survival advantage (P=0.028). Conclusions: Diagnosis of CRC should not be excluded solely on the basis of age. CRC features in young-adult patients are more similar to adults compared with that of child-adolescent patients according to the symptoms and presentation. In patients with CRC in this age group, curative surgery, adjuvant chemotherapy, and palliative chemotherapy provide survival advantage.en_US
dc.identifier.doi10.1097/MPH.0b013e31827e7f20en_US
dc.identifier.endpage89en_US
dc.identifier.issn1077-4114en_US
dc.identifier.issue2en_US
dc.identifier.pmid23337551en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MPH.0b013e31827e7f20
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29295
dc.identifier.volume35en_US
dc.identifier.wosWOS:000315357100013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcolorectal canceren_US
dc.subjectyoungen_US
dc.subjectadolescenten_US
dc.subjectchildhooden_US
dc.titleChildhood, Adolescents, and Young Adults (<= 25 y) Colorectal Cancer: Study of Anatolian Society of Medical Oncologyen_US
dc.typeArticleen_US

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