In vitro antioxidant and enzyme inhibitory properties of Rubus caesius L

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dc.contributor.authorGrochowski, Daniel Miroslaw
dc.contributor.authorUysal, Şengül
dc.contributor.authorZengin, Gökhan
dc.contributor.authorTomczyk, Michal
dc.date.accessioned2020-03-26T20:14:39Z
dc.date.available2020-03-26T20:14:39Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThe genus Rubus (Rosaceae) has great potential for and a history of use as natural agents in several traditional folk remedies. Based on this concept, this study focused on the antioxidant activities and enzyme inhibitory effects of extracts and fractions from Rubus caesius. Different chemical assays were performed to detect antioxidant capacity, namely, free radical scavenging (ABTS and DPPH assays), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating. Enzyme inhibitory effects were tested towards cholinesterases (AChE and BChE), tyrosinase, alpha-amylase and alpha-glucosidase. In addition, total amounts of phenolics and flavonoids were detected by colorimetric assays. Among the samples, the ethyl acetate fraction exhibited the strongest antioxidant potential with its higher concentration of total phenolics. The highest AChE and alpha-amylase inhibitory activities were observed in the diethyl ether fraction, while the n-butanol fraction had the strongest anti-tyrosinase inhibitor ability. The present study demonstrated that R. caesius may be considered a source of biologically active compounds to develop novel functional products or drugs in the pharmaceutical field.en_US
dc.description.sponsorshipMedical University of Bialystok [OP DEP 2007-2013]; [POPW.01.03.00-20-001/12]; [N/ST/MN/17/001/2212]en_US
dc.description.sponsorshipThis work was supported by Medical University of Bialystok [grant number OP DEP 2007-2013]; Priority Axis I.3 [contract no. POPW.01.03.00-20-001/12], [grant number N/ST/MN/17/001/2212].en_US
dc.identifier.citationGrochowski, D. M., Uysal, S., Zengin, G., Tomczyk, M. (2019). In Vitro Antioxidant And Enzyme İnhibitory Properties Of Rubus Caesius L. International Journal Of Environmental Health Research, 29,(3), 237-245.
dc.identifier.doi10.1080/09603123.2018.1533532en_US
dc.identifier.endpage245en_US
dc.identifier.issn0960-3123en_US
dc.identifier.issn1369-1619en_US
dc.identifier.issue3en_US
dc.identifier.pmid30311781en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage237en_US
dc.identifier.urihttps://dx.doi.org/10.1080/09603123.2018.1533532
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37914
dc.identifier.volume29en_US
dc.identifier.wosWOS:000463919900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUysal, Sengul
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRubus caesiusen_US
dc.subjectRosaceaeen_US
dc.subjectantioxidant activityen_US
dc.subjectenzyme inhibitory activityen_US
dc.subjectpolyphenolic compoundsen_US
dc.titleIn vitro antioxidant and enzyme inhibitory properties of Rubus caesius Len_US
dc.typeArticleen_US

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